Flurbiprofen

Drug #320

Flurbiprofen is NSAID (non-steroidal anti-inflammatory drug). Flurbiprofen is a propionic acid derivative and structurally related to ibuprofen. Flurbiprofen is used to relieve pain and to reduce inflammation or swelling and fever. Flurbiprofen is used in the treatment of pain, swelling and stiffness associated with arthritis and as eye drops to prevent trauma-induced pupil constriction during surgery.

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Primary Characteristics

Flurbiprofen is also known as Flurbiprofen Sodium.

It is of Synthetic origin and belongs to Propionic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Propionic Acid pharmacological group. It is also classified under Opthalmic Products .

Molecular Weight: 244.3 · Solubility in Water: slightly soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Flurbiprofen.

Pharmacokinetics

Absorption: Flurbiprofen has an oral bioavailability is 97% (±2%).

Distribution: Flurbiprofen has a volume of distribution is 0.1 l/kg. plasma protein binding is 99%.

Elimination: plasma half-life is 3.5 hr, renal excretion is 95%.

Indications

Flurbiprofen is primarily indicated in conditions like Adjunct in GI-disorders, Ankylosing spondylitis, Dysmenorrhoea, Gout, Juvenile chronic arthritis, Mild to moderate pain, Musculoskeletal disorders, Nausea and vomiting (palliative care), Non-steroidal anti-inflammatory drugs (NSAID), Osteoarthritis, Pain, Post operative analgesia, Rheumatoid arthritis.

Contraindications

Flurbiprofen is contraindicated in conditions like Peptic ulcer, Ulcerative colitis, Bronchospasm.

Dosage

Flurbiprofen's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.03 %	0.03 %	—	Ophthalmic	As Required.To be given as drops.
87.5 mg	87.5 mg	Every 12h	PO	Max. 300mg daily
Paediatric Dosage (20kg)
3 mg/kg	3 mg/kg	Every 24h	Oral	-
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown6 interactions

4 interactions

Major1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Flurbiprofen produces potentially life-threatening effects which include Hemorrhage , Peptic ulceration, Perforation . Careful monitoring is needed with proper medical management.

Flurbiprofen is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Cutaneous vasculitis, Deafness , Dizziness, Epidermal necrosis, Exfoliative dermatitis, GI reactions, Lichinoid eruptions, Peripheral edema, Tinnitus.

Warnings / Precautions

Flurbiprofen should be used with caution in patients with history especially of any liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergies, especially drug allergies. It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Caution is advised when this drug is used in the elderly. This medication should be used during pregnancy or lactation only if clearly needed. Use of this drug during the last 6 months of pregnancy is not recommended.

Interference in Pathology

Flurbiprofen may interfere in the diagnosis of Abnormal LFTs , Complete blood cell count.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

Caps SR

Eye Drops

Gel

Tabs

Tabs SR

Storage Conditions

Flurbiprofen should be stored Eye Drops . Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)
2.2.5 — Antirheumatics, topical
3.21.2.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers

Manufacturers of Flurbiprofen in Pakistan: