Flurazepam (HCl)

Drug #319

Flurazepam (HCl) is a 1,4-benzodiazipine with long duartion of action. A substituent in the 7th position such as halogen or a nitro group is required for its sedative- hypnotic activity. Benzdiazipines are the most widely used anxiolytic drugs. The benzodiazipines are more effective and safer. They have largely replaced barbiturates and meprobamate in the treatment of anxiety.

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Primary Characteristics

It belongs to Benzodiazepine.

It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group. It is also classified under Sedatives and Hypnotics .

Molecular Weight: 460.8 · pK_a: 1.9 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 4 · Non-proprietary name: Flurazepam (HCl).

Pharmacokinetics

Absorption: Flurazepam (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 70%.

Distribution: Flurazepam (HCl) has a plasma protein binding is 97%.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 2.5 hr, renal excretion is >60%.

Indications

Flurazepam (HCl) is primarily indicated in conditions like Hypnotic, Insomnia, Nausea, vertigo, labyrinthine disorders, NSAID-associated gastric and duodenal ulcers and duodenal errosions.

Contraindications

Flurazepam (HCl) is contraindicated in conditions like Myasthenia gravis, Respiratory depression, Sleep apnea syndrome, Acute pulmonary insufficiency.

Dosage

Flurazepam (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.321 mg/kg	0.321 mg/kg	Every 24h	PO	At Bed Time
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

2 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Flurazepam (HCl) in overdosage may give rise to further complications which include Aggression, Anxiety .

Flurazepam (HCl) produces potentially life-threatening effects which include Anaphylactoid reactions . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Flurazepam (HCl) are Drowsiness, Ataxia, Dysarthria .

Flurazepam (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Diminished libido, Drowsiness, Feeling of hangover, Hypotension , Light headedness, Nausea, Respiratory depression, Slurred speech, VertigoX.

Warnings / Precautions

Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. It should be used with caution in patients with respiratory disease, muscle weakness, history of drug or alcohol abuse, marked personality disorder; avoid regular use during pregnancy (risk of neonatal withdrawl symptoms); use only if clear indication such as seizure control (high doses during late pregnancy or labour may cause neonatal hypothermia, hypotonia and respiratory depression); breast-feeding (present in milk, avoid if possible); reduce dose in elderly and debilitated, and in hepatic (avoid if severe) and renal impairment (start with small doses if severe); avoid prolong use (abrupt withdrawl thereafter); porphyria. It should not be used alone to treat depression (or anxiety associated with depression) or psychosis

Available Brands

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Single Ingredient

Tabs

15 mg

Storage Conditions

Flurazepam (HCl) should be stored Caps.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders

Manufacturers

Manufacturers of Flurazepam (HCl) in Pakistan:

Evron