Fluphenazine
Fluphenazine is antipsychotic drug, also called as neuroleptic drug. Fluphenazine is the 2-trifluromethyl derivative of perphenazine, the most potent of phenothiazine tranquilizers. Fluphenazine is effective in treatment of schizophrenia, manic states and delirium.
Primary Characteristics
Fluphenazine is also known as Fluphenazine decanoate.
It is of Synthetic origin and belongs to Phenothiazine.
It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Antipsychotic Agent pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 437.5 · pKa: 3.9 · Solubility in Water: 1 in 10 · Solubility in Alcohol: > 1 in 1000 · Non-proprietary name: Fluphenazine.
Pharmacokinetics
Absorption: Fluphenazine has an pre-systemic (first-pass) metabolism accounts for 55% (±5%).
Distribution: Fluphenazine has a volume of distribution is high. plasma protein binding is >90%.
Elimination: it is metabolised via >60% by liver, plasma half-life is 16.4 hr, renal excretion is 20%.
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Indications
Fluphenazine is primarily indicated in conditions like Diagnostic procedures, Hypothyroidism, Mania, Muscle spasm of varied aeitology, Post-operative nausea and vomiting, Psychosis, Relief of discomfort in mild UTIs.
Contraindications
Fluphenazine is contraindicated in conditions like Blood dyscrasias, Hepatic disease, Coma, Brain damage.
Dosage
Fluphenazine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 18.75 mg | 18.75 mg | — | IM | Initial |
| 62.5 mg | 62.5 mg | — | IM | Maintenance with 2-5 week dose intervals |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Fluphenazine in overdosage may give rise to further complications which include Neurological disturbances , Tardive dyskinesia .
Fluphenazine produces potentially life-threatening effects which include Blood dyscrasias, Malignant neuroplastic syndrome. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Fluphenazine are Hypotension, Hypothermia, Tachycardia , Tachypnea.
Fluphenazine is known to cause more or less tolerable side effects which are usually transient. These include Adverse behavioral reactions, Adverse neurological symptoms, Allergic reactions, ANS adverse effects, Cholestatic Jaundice , Deposits in lense & cornea, Galactorrhea, HyperprolactinemiaX, Skin pigmentation.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.1 — Drugs used in psychotic disorders