Flupenthixol (HCl and Decanoate)
Also known as: Flupentixol Decanoate
Flupenthixol (HCl and Decanoate) is a tranquillizer. Flupenthixol (HCl and Decanoate) is used in depressive and anxiety states associated with inertia and apathy.
Primary Characteristics
Flupenthixol (HCl and Decanoate) is also known as Flupentixol Decanoate.
It belongs to Thioxanthene.
It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Antidepressant Tricyclic pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 507.4 · pKa: 3.4 · Solubility in Water: > 1 in 30 · Solubility in Alcohol: >1 in 30 · Non-proprietary name: Flupenthixol (HCl and Decanoate).
Pharmacokinetics
Absorption: Flupenthixol (HCl and Decanoate) has an oral bioavailability is 82.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 40%.
Distribution: Flupenthixol (HCl and Decanoate) has a volume of distribution is 14 l/kg. plasma protein binding is >95%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 35 hr, renal excretion is minor.
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Indications
Flupenthixol (HCl and Decanoate) is primarily indicated in conditions like Depression, Depressive illness, Enhance permeation of SC or IM inj, Muscle spasm of varied aeitology, Pain, Personality disorder, Post-operative nausea and vomiting, Psychosis, Relief of discomfort in mild UTIs, Schizophrenia.
Contraindications
Flupenthixol (HCl and Decanoate) is contraindicated in conditions like Parkinsonism, Coma.
Dosage
Flupenthixol (HCl and Decanoate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 mg | 1.5 mg | Every 24h | PO | For depression Max dose 3 mg. |
| 30 mg | 30 mg | — | PO | For psychosis. Initialy 20 mg. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Flupenthixol (HCl and Decanoate) produces potentially life-threatening effects which include Tachycardia, Cardiac arrhythmias, Neuroleptic Malignant Syndrome , B.P instability. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Flupenthixol (HCl and Decanoate) are Coma, Hyperthermia, Convulsions , Shock, Somnolence.
Flupenthixol (HCl and Decanoate) is known to cause more or less tolerable side effects which are usually transient. These include Breast engorgement, Dry mouth, Erectile disturbance, Loss of libido, Menstrual irregularity, Muscle rigidity, Transient insomnia, Tremor, Weight gain.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression