Fluoxetine (HCl)

Drug #316

Fluoxetine (HCl) is the prototype of antidepressant drug that selectively inhibits sertotonin reuptake. Selective serotonin reuptake inhibitors (SSRIs) is the new class of chemically unique antidepressant drugs that specifically inhibFluoxetine (HCl) is serotonin reuptake.

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Primary Characteristics

Fluoxetine (HCl) is also known as Fluoxetine.

It is of Synthetic origin and belongs to Propylamine.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 345.8 · Solubility in Water: 1 in 71 · Non-proprietary name: Fluoxetine (HCl).

Pharmacokinetics

Absorption: Fluoxetine (HCl) has an oral bioavailability is 47.5% (±47.5%).

Distribution: Fluoxetine (HCl) has a volume of distribution is 20-42 l/kg. plasma protein binding is 94-98%.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 48-72hr (single dose)7-15days(plus metabolites), renal excretion is 60-80%.

Indications

Fluoxetine (HCl) is primarily indicated in conditions like Bulimia nervosa, Control of muscarinic side-effects of neostigmine, Depression, Depressive illness, Obsessive-compulsive disorders, Panic disorders, Parkinson's disease, Suspected methotrexate overdosage.

Fluoxetine (HCl) is also indicated for secondary conditions like Fibromyalgia.

Contraindications

Fluoxetine (HCl) is contraindicated in conditions like Renal failure, Hypersensitivity.

Dosage

Fluoxetine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
50 mg	50 mg	Every 24h	PO	If inadequate response, increase the dose no more often than every month by 10-20 mg/kg/day to a maximum of 80 mg/day.
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown14 interactions

16 interactions

Major1 interaction

Minor2 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fluoxetine (HCl) in overdosage may give rise to further complications which include Serum sickness , Vasculitis , Seizures , Extrapyramidal symptoms, Sinus bradycardia , Mania , Altered platelet function , Hypersensitivity pneumonitis, Leucocytoclastic vasiculitis.

The signs and symptoms that are produced after acute overdosage of Fluoxetine (HCl) are Vomiting, Grand Mal Seizures (epilepsy), CNS excitation, Hypomania, Agitation, Nausea, Restlessness .

Fluoxetine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Anxiety, Asthenia , Diarrhea, Dizziness, Drowsiness, Elevation of liver enzymes, Erythema multiforme, Fatigue, GI upset, Hyponatremia, Insomnia, Nausea, nervousness, Palpitation, Sinus tachycardia, Sinusitis , SweatingX, Termors, Vison disturbance, Weight LossX.

Warnings / Precautions

Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Fluoxetine should be used with caution in patient with history of seizures, in kidney or liver impairment, with diseases or conditions that could effect metabolism or hemodynamic response.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caplet

Caps

Liquid

Syrup

Tabs

Multi-Ingredient Combinations

Caps

25 mg

Storage Conditions

Fluoxetine (HCl) should be stored Caps, Soln.

Drug Classification

1.24.2.1 — Drugs used in depression