DrugInfoSys

Fluocinolone (Acetonide)

Also known as: Flucinolone

Drug #308

Fluocinolone (Acetonide) is a corticosteroid (class of steroid hormones formed in the adrenal gland ). Fluocinolone (Acetonide) is used to educe swelling, inflammation and itching of skin in conditions such as psoriasis, eczema, dermatitis, rashes, insect bites, and allergies etc.

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Primary Characteristics

Fluocinolone (Acetonide) is also known as Flucinolone.

It is of Synthetic origin and belongs to Corticosteroid .

It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Topical pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 452.5 · pKa: unionized · Solubility in Water: almost insoluble · Solubility in Alcohol: 1 in 26 · Non-proprietary name: Fluocinolone Acetonide.

Molecular structure of Fluocinolone (Acetonide)

Pharmacokinetics

Distribution: Fluocinolone (Acetonide) has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is .

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Indications

Fluocinolone (Acetonide) is primarily indicated in conditions like Dermatitis, Eczema, Flexural psoriasis, Lichen planus, Lichen simplex, Lupus erythematosus, Necrobiosis lipoidica.

Contraindications

Fluocinolone (Acetonide) is contraindicated in conditions like Bacterial infections, Fungal infection, Viral infection, Ulcers, Acne vulgaris, Rosacea, Perioral dermatitis.

Dosage

Fluocinolone (Acetonide)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.025 %0.025 %Every 8hTopical -
Paediatric Dosage (20kg)
0.025 %0.025 %Every 8hTopical -
Neonatal Dosage (3kg)
0.025 %0.025 %Every 8hTopical -

Drug Interactions

None recorded.

Side Effects

Fluocinolone (Acetonide) in overdosage may give rise to further complications which include Cataract, Adrenal suppression , Telangiectasia, Striae , Secondary infections , Glaucoma , Growth retardation , Epidermal thinning , Raised intracranial pressure .

Fluocinolone (Acetonide) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Perioral dermatitis, Rebound pustulation .

Warnings / Precautions

Flucinolone acetonide should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.

Interference in Pathology

Fluocinolone (Acetonide) may interfere in the diagnosis of ACTH Stimulation test, Urinary free cortisol test, ACTH stimulation test.

Available Brands

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Single Ingredient

Cream
0.025 %w/w
Gel
0.01 % v/w0.025 %w/w
Oint
0.025 %w/w

Multi-Ingredient Combinations

Cream
0.01 %w/w0.01 g0.025 %w/w
Cream
0.03 %w/w
Eye Drops
0.4 %w/v
Gel
0.03 %w/w
Oint
0.025 %w/w
Oint
0.03 %w/w

Storage Conditions

Fluocinolone (Acetonide) should be stored Cream, Oint.

Drug Classification

  1. 1.13.3.1 — Corticosteroids plain

Manufacturers