Fenoterol
Fenoterol is a direct acting sympathomimetic with beta adrenoceptor stimulant and is used as bronchodilator. Fenoterol (HBr) used only in the management of acute episode of asthma. Fenoterol (HBr) relaxes the smooth muscle in the lungs and expands the bronchi (air ways) in lungs and makes the breathing easy.
Primary Characteristics
Fenoterol is also known as Fenoterol (HBr).
It is of Synthetic origin and belongs to Phenylethanol HBr.
It belongs to Beta-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Anti-inflammatory , Bronchodilator , Analgesic pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 384.3 · pKa: 8.5 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1 in 11 · Non-proprietary name: Fenoterol.
Pharmacokinetics
Absorption: Fenoterol has an pre-systemic (first-pass) metabolism accounts for 75% (±5%).
Elimination: it is metabolised via extensive by liver, plasma half-life is 6.5 hr, renal excretion is 35%.
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Indications
Fenoterol is primarily indicated in conditions like Asthma, Bronchitis, Bronchospasm, Labor pains.
Contraindications
Fenoterol is contraindicated in conditions like Eclampsia.
Dosage
Fenoterol 's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.5 – 2.5 mg | — | Every 6h | Inhalation | Chronic reversible airways obstruction |
| 0.1 – 0.2 mg | — | Every 24h | Meter dose Aerosol | Acute reversible airway disease. |
| Paediatric Dosage (20kg) | ||||
| 8 ug/kg | 8 ug/kg | Every 8h | Inhalation | Recommended for 6-12 Years of Children |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Fenoterol in overdosage may give rise to further complications which include Flushing , Dizziness , Hives.
Fenoterol produces potentially life-threatening effects which include Sudden death, Dysrhythmias. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Fenoterol are Tachycardia , Palpitations , Tremulousness , Irregularities in heart rhythm.
Fenoterol is known to cause more or less tolerable side effects which are usually transient. These include Coughing, Dry mouth, Headache, Nervousness, Trembling, Tremor.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.21.4.3 — Sympathomimetics
- 2.25.1.1 — Oral/Parenteral antiasthmatics
- 3.25.1.2 — Inhalants