Fenoprofen

Also known as: Fenopron, Fepron, Feprona, Nalfon +2 more

Drug #302

Fenoprofen is NSAID (non-steroidal anti-inflammatory drug). Fenoprofen is a propionic acid derivative.Fenoprofen is used to relieve pain and to reduce fever and inflammation or swelling. Fenoprofen is used to treat pain, swelling and stiffness associated with arthritis. Fenoprofen is also used to treat headaches, dental pain and athletic injuries.

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Primary Characteristics

Fenoprofen is also known as Fenopron, Fepron, Feprona, Nalfon, Nalgesic, Progesic.

It is of Synthetic origin and belongs to Propionic Acid Derivative.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 558.6 · pK_a: 4.5 · Solubility in Water: > 1 in 500 · Solubility in Alcohol: 1 in 15 · Non-proprietary name: Fenoprofen.

Pharmacokinetics

Absorption: Fenoprofen has an oral bioavailability is 85% (±5%).

Distribution: Fenoprofen has a volume of distribution is 0.1 l/kg. plasma protein binding is 99%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 2.2 hr, renal excretion is >90%.

Indications

Fenoprofen is primarily indicated in conditions like Fever, Mild to moderate pain, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Rheumatoid arthritis.

Contraindications

Fenoprofen is contraindicated in conditions like Peptic ulcer, Renal failure.

Dosage

Fenoprofen's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5.714 mg/kg	5.714 mg/kg	Every 24h	PO	As Required
300 mg	300 mg	Every 8h	PO	Analgeric Fever.
400 mg	400 mg	Every 8h	PO	Anti-inflamnatory
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown5 interactions

1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fenoprofen in overdosage may give rise to further complications which include Renal damage , Thrombocytopenia , Allergic reactions , Bronchospasm , Stevens johnson syndrome , Bronchospasm , Stevens johnson syndrome , Angioedema , Angioedema , Pancytopenia , Papillary necrosis , Glomerular toxicity , Allergic nephritis .

Fenoprofen produces potentially life-threatening effects which include GI bleeding, GI irritation, Dyspepsia , Peptic ulceration, Gastric hemorrhage, Hematuria, Proteinuria. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Fenoprofen are Hematuria, Acute renal failure, Headache, Proteinuria, Low abdominal pain, Tinnitus , Tinnitus.

Fenoprofen is known to cause more or less tolerable side effects which are usually transient. These include Ambylopia , Blurred vision, Buccal ulceration, Confusion, Constipation , Cystitis, Deafness , Diarrhea, Dizziness, Dysuria, Headache, Increased intracranial pressure, Nausea and vomiting, Peripheral edema, Sleep disturbancesX, Termors, Tinnitus.

Warnings / Precautions

Fenprofen should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occur.

Interference in Pathology

Fenoprofen may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

None recorded.

Storage Conditions

Fenoprofen should be stored Caps, Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)