Fentanyl (Citrate)
Also known as: Phentonyl, Pentanyl, Fentanest
Fentanyl (Citrate) is a narcotic analgesic derivative of piperidine. Fentanyl (Citrate) is chemically related to meperidine. It has 80 time the analgesic potency of morphine, used mainly preoperatively, postoperatively and during surgery. Fentanyl (Citrate) is administred intravenously or intramuscularly.
Primary Characteristics
Fentanyl (Citrate) is also known as Phentonyl, Pentanyl, Fentanest.
It is of Synthetic origin and belongs to Opioid.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic pharmacological group.
Molecular Weight: 528.6 · pKa: 8.43 · Solubility in Water: 1 in 40 · Solubility in Alcohol: 1 in 140 · Non-proprietary name: Fentanyl (Citrate).
Pharmacokinetics
Distribution: Fentanyl (Citrate) has a volume of distribution is 3 l/kg. plasma protein binding is 80%.
Elimination: it is metabolised via rapid by liver, plasma half-life is 3.7 hr, renal excretion is >67%.
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Indications
Fentanyl (Citrate) is primarily indicated in conditions like Analgesia during operation, enhancement of anaesthesia, Pain.
Fentanyl (Citrate) is also indicated for secondary conditions like Anesthesia.
Contraindications
Fentanyl (Citrate) is contraindicated in conditions like Hypovolaemia, Hypotension, Raised intracranial pressure, Respiratory insufficiency.
Dosage
Fentanyl (Citrate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.071 ug/kg | 1.071 ug/kg | — | IM | 30-60 Min before anaesthesia |
| Paediatric Dosage (20kg) | ||||
| 2.2 ug/kg | 2.2 ug/kg | — | Intra Muscular | For Induction and Maintenance ,not safe below 2 Yrs. |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not safe under 2 Yrs of children | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Fentanyl (Citrate) in overdosage may give rise to further complications which include Glottic closure .
Fentanyl (Citrate) produces potentially life-threatening effects which include Respiratory depression. Careful monitoring is needed with proper medical management.
Fentanyl (Citrate) is known to cause more or less tolerable side effects which are usually transient. These include Nausea and vomiting, Urinary retensionX.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics
Manufacturers
Manufacturers of Fentanyl (Citrate) in Pakistan: