Fenfluramine (HCl)

Drug #301

Fenfluramine (HCl) is antiobesity drug and has anorectic effects. Fenfluramine (HCl) is a racemic chemical, closely related to amphetamine. It was introduced as an anorexigenic drug more than a decade ago in Europe. its d-isomer, d-fenfluramine is about twice as potent an anorexigenic drug as fenfluramine, suggesting that all of the fenfluramine activity reside in the d-form.

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Primary Characteristics

It is of Synthetic origin and belongs to Anphetamine.

It belongs to Anorectic Agent pharmacological group on the basis of mechanism of action and also classified in Selective Serotonin Reuptake Inhibitor pharmacological group. It is also classified under CNS Stimulant .

Molecular Weight: 267.7 · pK_a: 10 · Solubility in Water: 1 in 20 · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Fenfluramine (HCl).

Molecular structure of Fenfluramine (HCl)

Pharmacokinetics

Absorption: Fenfluramine (HCl) has an oral bioavailability is 97% (±2%).

Distribution: Fenfluramine (HCl) has a plasma protein binding is 30%.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 11-30 hr, renal excretion is >90%.

Indications

Fenfluramine (HCl) is primarily indicated in conditions like Obesity.

Fenfluramine (HCl) is also indicated for secondary conditions like Hypertension, Maturity onset diabetes.

Contraindications

Fenfluramine (HCl) is contraindicated in conditions like Depression, Mania, Cardiovascular disease.

Dosage

Fenfluramine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 20 mg	—	Every 12h	PO	Intially for 1 Week
40 – 80 mg	—	Every 12h	PO	Maintenance, As Required
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown10 interactions

1 interaction

Major2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fenfluramine (HCl) in overdosage may give rise to further complications which include Tachycardia , Impotence , Anorexia , Coma , Depression , Dizziness , Respiratory depression , Abdominal cramps.

Fenfluramine (HCl) produces potentially life-threatening effects which include Blood dyscrasias, Pulmonary hypertension. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Fenfluramine (HCl) are Flushing, Tachycardia , Cardiac arrhythmias, Convulsions , Coma, Hyperthermia, Hallucinations , Sweating , Tachypnea, Hyperpyrexia, Tremor, Mydriasis, Nystagmus, Excitation , Sweating, Increased tendon reflexes, Chest pain.

Fenfluramine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Drowsiness, Dry mouth, Impotence, Insomnia, Irritability, Lethargy, Loss of libido, Nausea, Rashes , Restlessness, Urinary frequency, Vomiting .

Warnings / Precautions

Avoid Fenfluramine in patients with pulmonary hypertension, past or current history of cardiovascular or cerebrovascular disease, psychiatric disease, glaucoma, epilepsy, history of drug abuse. It should be used with extreme caution in elderly or during pregnancy or lactation. Avoid abrupt withdrawal. Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness, extreme fatigue and depression. It should be usedwith caution and monitor blood pressure (B.P) in patients with mild hypertension. Dose titration and dose discontinuance may be necessary in epileptic patients. Height and weight should be monitored as fenfluramine may cause growth retardation.

Interference in Pathology

Fenfluramine (HCl) may interfere in the diagnosis of Plasma Cortisol Measurement. , Serum Triglycerides Measurement. .

Available Brands

None recorded.

Storage Conditions

Fenfluramine (HCl) should be stored Tab.

Drug Classification

1.17.10 — Antiobesity preparations