Fenbufen

Drug #300

Fenbufen is NSAID (non-steroidal anti-inflammatory drug). Fenbufen is used to relieve pain and to reduce inflammation or swelling and fever. Fenbufen is used to treat pain, swelling and stiffness associated with arthritis.

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Primary Characteristics

It is of Synthetic origin and belongs to Oxobutyric Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 254.3 · pK_a: 5.7 · Solubility in Water: 1 in 9000 · Solubility in Alcohol: 1 in 250 · Non-proprietary name: Fenbufen.

Pharmacokinetics

Absorption: Fenbufen has an oral bioavailability is 80%, pre-systemic (first-pass) metabolism accounts for 1% (±1%).

Distribution: Fenbufen has a plasma protein binding is 98%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 13.5 hr, renal excretion is 47%.

Indications

Fenbufen is primarily indicated in conditions like Ankylosing spondylitis, Gout, Musculoskeletal disorders, Osteoarthritis, Pain, Rheumatoid arthritis.

Fenbufen is also indicated for secondary conditions like Dental surgery, Nausea and vomiting (palliative care).

Contraindications

Fenbufen is contraindicated in conditions like Peptic ulcer, Pregnancy, Breast feeding, Resistant dermatophyte infections of skin or finger nails (not toe nails).

Dosage

Fenbufen's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 900 mg	—	Every 12h	PO	In dividid doses of 450mg morning & 450mg evening
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown11 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fenbufen in overdosage may give rise to further complications which include Stevens johnson syndrome , Stevens johnson syndrome , Erythema multiforme, Erythema multiforme , upper respiratory tract infection, Upper respiratory tract infection, Nasophyringitis.

Fenbufen produces potentially life-threatening effects which include GI bleeding. Careful monitoring is needed with proper medical management.

Fenbufen is known to cause more or less tolerable side effects which are usually transient. These include Anuria , athralgia, Azotemia, Decrease in hematocrit, Decrease in hemoglobin, Decrease in leucocytes, Fever, Fluid retention, GI upset, Increase in eosinophils, Increase in prothrombin time, Neurological effects, Oliguria, Rashes , Skin rashes.

Warnings / Precautions

In patients with renal, cardiac, or hepatic impairment caution is required since NSAIDs may impair renal function; the dose should be kept as low as possible and renal function should be monitored. Should be used with caution in patients with peptic or intertinal ulceration.

Available Brands

None recorded.

Storage Conditions

Fenbufen should be stored Tab, Caps.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)