Factor VIII

Also known as: Anti-haemophilic Factor

Drug #297

Factor VIII is a blood clotting factor. Factor VIII is used to stop episodes of uncontrollable bleeding in hemophilia and von willebrand's disease.

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Primary Characteristics

Factor VIII is also known as Anti-haemophilic Factor.

It is of Natural origin and belongs to Glycoprotein.

It belongs to Blood Coagulation pharmacological group on the basis of mechanism of action. It is also classified under Hematological Agents .

Molecular Weight: 330000 · pK_a: 0 · Solubility in Water: moderate · Solubility in Alcohol: insoluble · Non-proprietary name: Factor VIII · pH: 6.5 · Isotonic value: 240.

Pharmacokinetics

Distribution: Factor VIII has a volume of distribution is 0.04-0.10 l/kg. plasma protein binding is >95%.

Elimination: it is metabolised via Plasma & Hepatic, plasma half-life is 8-12hr.

Indications

Factor VIII is primarily indicated in conditions like Haemophilia, Haemorrhage, Von willebrand's disease.

Factor VIII is also indicated for secondary conditions like Willebrand's disease.

Contraindications

Factor VIII is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Factor VIII's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
20 – 40 IU/dl	—	—	Slow IV	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Factor VIII in overdosage may give rise to further complications which include Hepatitis , Paraesthexia.

Factor VIII produces potentially life-threatening effects which include Anaphylaxis , Fluminating hepatitis, AIDS . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Factor VIII are Paradoxical hemorrhage, Coombs positive hemolytic anemia.

Factor VIII is known to cause more or less tolerable side effects which are usually transient. These include Chills fever, Drowsiness, Dyspnoea, Fulness in head, GI disturbance, Headache, Palpitation, Urticaria, Warm flush.

Warnings / Precautions

It should be used only if clearly needed during pregnancy. It should be used with cauiton in patients with any pre-existing diseases or any allergies.Before and during injection check heart rate.The dose or rate of infusion may need to be changed if heart rate is too fast. Monitor for development of factor VIII inhibitors, Intravascular haemolysis after large or frequently repeated doses in patients with blood groups A, B or AB

Available Brands

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Single Ingredient

Inj

250 IU

Storage Conditions

Factor VIII should be stored Inj.

Drug Classification

1.11.2 — Plasma fractions for specific use

Manufacturers

Manufacturers of Factor VIII in Pakistan:

Popular Int.