Famotidine
Also known as: Famotidin, Famotidina, Famotidinum
Famotidine was introduced in mid 1970s. Famotidine is a histamine H2 receptor blocker and inhibits secretion of gastric acid produced by histamine. itused to treat and prevent duodenal and peptic ulcers, zollinger-ellison syndrome (hypersecretion of HCl) to treat gastroesophageal reflux disorder (heart burn).
Primary Characteristics
Famotidine is also known as Famotidin, Famotidina, Famotidinum.
It is of Synthetic origin and belongs to Sulphamoylpropionamidine.
It belongs to H2-antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 337.5 · pKa: 7.1 · Solubility in Water: slightly soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Famotidine.
Pharmacokinetics
Absorption: Famotidine has an oral bioavailability is 40%, pre-systemic (first-pass) metabolism accounts for 2.5% (±2.5%).
Distribution: Famotidine has a volume of distribution is 1.1-1.4 l/kg. plasma protein binding is 15-20%.
Elimination: plasma half-life is 2.5-4 hr, renal excretion is >40%.
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Indications
Famotidine is primarily indicated in conditions like Benign gastric and duodenal ulceration, Benign gastric ulcer, Duodenal ulceration, Duodenal ulcer, Duodenal ulcer relapse prophylaxis, Reflux oesophagitis, Zollinger-ellison syndrome.
Famotidine is also indicated for secondary conditions like Dyspepsia, Heart burn.
Contraindications
Famotidine is contraindicated in conditions like Hypersensitivity, Gastric malignancy.
Dosage
Famotidine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 20 mg | 20 mg | Every 12h | IV | |
| 30 mg | 30 mg | Every 24h | PO | At bedtime. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Safety not established | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Safety not established | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Famotidine produces potentially life-threatening effects which include Blood dyscrasias. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Famotidine are Tachycardia , Emesis, Hypotension, Restlessness .
Famotidine is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Constipation , Diarrhea, Dizziness, Epidermal necrolysis, Headache, Hypotension , Jaundice , Mental confusion, Renal failure.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.17.1.2 — Anti-peptic ulcerants
Manufacturers
Manufacturers of Famotidine in Pakistan: