Etodolac

Drug #293

Etodolac is a newer pyranoindole acetic acid derivative. Etodolac is NSAID (non-steroidal anti-inflammatory drug). It relieves pain and reduces fever and inflammation. Etodolac is a racemic mixture of R and S forms, the R form being inactive. itused to treat pain, swelling and stiffness associated with arthritis.

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Primary Characteristics

It is of Synthetic origin and belongs to Pyranoindole Acetic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 287.4 · pK_a: 4.65 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1 in 4 · Non-proprietary name: Etodolac.

Pharmacokinetics

Absorption: Etodolac has an oral bioavailability is 78% (±5%).

Distribution: Etodolac has a volume of distribution is 0.41 l/kg. plasma protein binding is 99%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 6-7.4 hr, renal excretion is 74%.

Indications

Etodolac is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery, Osteoarthritis, Pain and inflammation in rheumatoid arthritis, Rheumatoid arthritis.

Contraindications

Etodolac is contraindicated in conditions like Peptic ulcer, GI hemorrhage.

Dosage

Etodolac's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.571 mg/kg	3.571 mg/kg	Every 24h	PO	For rheumatoid arthritis & for Osleoarthritis of hip & kneer for releiving pain after oral surgery
Paediatric Dosage (20kg)
0 – 0	—	—		Doses not established for this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Etodolac in overdosage may give rise to further complications which include Thrombocytopenia , Leucopenia.

Etodolac produces potentially life-threatening effects which include Gastrointestinal hemorrhage. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Etodolac are Upper gastrointestinal irritation.

Etodolac is known to cause more or less tolerable side effects which are usually transient. These include Indigestion , Photosensitivity reactions.

Warnings / Precautions

Etodolac should be used with caution in patients with liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergy, especially drug allergy. It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Do not take aspirin without consulting the doctor. Caution is advised when this drug is used in the elderly patients. This medication should be used during pregnancy or lactation only if clearly needed. The use of this drug in the last 6 months of pregnancy is not recommended.

Interference in Pathology

Etodolac may interfere in the diagnosis of False positive test for urinary bilirubin. .

Available Brands

None recorded.

Storage Conditions

Etodolac should be stored . Tab, Caps.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)