Etidronate (Disodium)

Drug #292

Etidronate is a diphosphonate compound, ethane-1-hydroxy-1,1-diphosphonate. It helps to maintain calcium levels and bone metabolism. Etidronate (Disodium) is used to treat osteoporosis and symptoms of paget's disease (bone weakening disease). Etidronate (Disodium) is also used after hip replacement or spinal cord injury.

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Primary Characteristics

It is of Synthetic origin and belongs to Diphosphonate.

It belongs to Osteoclast inhibitor pharmacological group on the basis of mechanism of action and also classified in Biphosphonate Derivative pharmacological group.

Molecular Weight: 250 · pK_a: 3.0, 2.2, 7.2, 11.1 · Solubility in Water: 1 in 20 · Solubility in Alcohol: < 1 in 50000 · Non-proprietary name: Etidronate (Disodium).

Molecular structure of Etidronate (Disodium)

Pharmacokinetics

Absorption: Etidronate (Disodium) has an oral bioavailability is 4.75% (±3.95%).

Distribution: Etidronate (Disodium) has a volume of distribution is 0.3-1.3 l/kg.

Elimination: plasma half-life is 2-6 hr, renal excretion is 50%.

Indications

Etidronate (Disodium) is primarily indicated in conditions like Bone (pagets) disease, Hypercalcaemia of malignancy, Postmenopausal osteoporosis.

Contraindications

Etidronate (Disodium) is contraindicated in conditions like Osteolytic paget's disease, Pregnancy, Breast feeding, Pain and inflammation (rheumatic disease), Vasomotor symptoms in estrogen deficiency, see instruction.

Dosage

Etidronate (Disodium)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
12.5 mg/kg	12.5 mg/kg	Every 24h	PO	For max 6 Months
Paediatric Dosage (20kg)
0 – 0	—	—		Safety not established
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Etidronate (Disodium) in overdosage may give rise to further complications which include Hypersensitivity rashes.

Etidronate (Disodium) produces potentially life-threatening effects which include Acute Renal Failure , Acute renal failure, Worsening of Pre-existing renal impairment. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Etidronate (Disodium) are Acute renal failure.

Etidronate (Disodium) is known to cause more or less tolerable side effects which are usually transient. These include Gastrointestinal Intolerance, Osteomalacia, Pathalogical fracture, Transient taste disturbances.

Warnings / Precautions

Patients who are on calcium and vitamin D restriction may be more sensitive to the effects of etidronate. Patients should be sure to maintain appropriate dietary intake of vitamin D and calcium while receiving this medication. Etidronate can cause diarrhea, particularly when high doses are administered, and the drug should be used with caution, if at all, in patients with enterocoliti. It should be used with caution in patients with renal impairment or a decreased glomerular filtration rate. It should be used during pregnancy only if the potential benefits to the mother outweighs thepotential risks to the fetus.

Interference in Pathology

Etidronate (Disodium) may interfere in the diagnosis of Interpretation of radionuclide bone scans..

Available Brands

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Single Ingredient

Tabs

200 mg 400 mg

Storage Conditions

Etidronate (Disodium) should be stored . Tab.

Drug Classification

1.18.14 — Drugs affecting bone metabolism

Manufacturers

Manufacturers of Etidronate (Disodium) in Pakistan:

Bosch Genix