Ethynodiol (Diacetate)
Ethynodiol (Diacetate) used as a contraceptive (to prevent pregnancy) or to regulate menstrual cycle.
Primary Characteristics
It is of Synthetic origin and belongs to Steroid.
It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action. It is also classified under Sex Hormones .
Molecular Weight: 384.4 · Solubility in Water: very slightly soluble · Solubility in Alcohol: 1 in 15 · Non-proprietary name: Ethynodiol (Diacetate).
Pharmacokinetics
Absorption: Ethynodiol (Diacetate) has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 75% (±5%).
Distribution: Ethynodiol (Diacetate) has a volume of distribution is 33 litre. plasma protein binding is extensive.
Elimination: it is metabolised via via liver & gut, plasma half-life is 25 hr.
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Indications
Ethynodiol (Diacetate) is primarily indicated in conditions like Contraception, Endometriosis, Functional uterine bleeding, Hirsutism.
Contraindications
Ethynodiol (Diacetate) is contraindicated in conditions like Circulatory system disease, Liver diseases, Genital tract bleeding, Hydatidiform mole, Harmonally-dependent neoplasms, Lipid metabolism disorder, Undiagnosed genital tract bleeding.
Dosage
Ethynodiol (Diacetate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0 – 0.5 mg | — | — | PO | On the first day of Menstraution and continued for desired duration of contracentive protection. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Indicated in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not indicated in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ethynodiol (Diacetate) in overdosage may give rise to further complications which include Carbohydrate intolerance , Lipid metabolism disturbance.
Ethynodiol (Diacetate) produces potentially life-threatening effects which include Myocardial infarction, Venous thromboemboli, Cerebrovascular disease. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Ethynodiol (Diacetate) are Vomiting, Breast swelling, Mastalgia , Nausea.
Ethynodiol (Diacetate) is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Breast tenderness, Changes in libido , Hyperphagia, Irregular uterine bleeding, Nausea, Vomiting , Weight gain.
Warnings / Precautions
Interference in Pathology
Ethynodiol (Diacetate) may interfere in the diagnosis of Elevated ESR and Haematocrit Values , Upset indices of Immunological Function .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.5 — Progestogens