Enoxacin

Also known as: Enoxacinum

Drug #277

Enoxacin is a fluoroquinolone antibiotic. They are relatively non-toxic, well tolerated broad spectrum agents. Their excellent bioavailibilty permits their use for treatment of variety of serious bacterial infections.Enoxacin is antibiotic used to treat infections of the urinary tract and sexually transmitted diseases. It's act by inhibiting DNA gyrase and topoisomerase IV, which are essential enzymes in the reproduction of bacterial DNA.

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Primary Characteristics

Enoxacin is also known as Enoxacinum.

It is of Synthetic origin and belongs to Quinolone.

It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 320.3 · Solubility in Water: 1 in 3333 · Non-proprietary name: Enoxacin.

Pharmacokinetics

Distribution: Enoxacin has a volume of distribution is 2.75 l/kg. plasma protein binding is 18-67%.

Elimination: it is metabolised via 15%, plasma half-life is 3-6 hr, renal excretion is >70%.

Indications

Enoxacin is primarily indicated in conditions like Bacterial infections, GI infections, Respiratory tract infections, Skin infections, Soft tissue infections, Urethritis, UTI.

Contraindications

Enoxacin is contraindicated in conditions like Tendinitis, Hypersensitivity to the drug.

Dosage

Enoxacin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
300 mg	300 mg	Every 12h	PO
400 mg	400 mg	Every 12h	PO	Single Dose for uncompleted gonorrhea
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown4 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Enoxacin in overdosage may give rise to further complications which include Hallucinations , Hallucinations , Eosinophilia , Eosinophilia , Elevated SGPT & SGOT, Seizures , Depression .

Enoxacin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anxiety, Arthralgia, Confusion, Depression, Diarrhea, Dizziness, Drowsiness, dyspepsia, Headache, Insomnia, Nausea and vomiting, Photosensitivity, Seizures and convulsions, Tremors.

Warnings / Precautions

Enoxacin should be used with caution in patient with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergy, including drug allergy. It should be used with caution while driving or performing tasks requiring alertness because it may produce dizziness or lightheadedness. Limit alcohol intake. Photosensitization may occur, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. This medication should be used only when clearly needed during pregnancy or lactation.

Interference in Pathology

Enoxacin may interfere in the diagnosis of Elevations of SGPT and SGOT , Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

400 mg

Tabs

400 mg

Storage Conditions

Enoxacin should be stored Tab.

Drug Classification

1.6.2.2.2 — Quinolones

Manufacturers

Manufacturers of Enoxacin in Pakistan:

Abbott Adamjee Fynk Mass Rasco Rock Saaaf Zafa