Enflurane

Also known as: Methylflurether

Drug #276

Enflurane is inhalation anesthetic. Inhaled gases are the mainstay of anesthesia and are primarily used for the maintenance of anesthesia after administration of an intravenous agent. The depth of anesthesia can be rapidly altered by changing the concentration of inhaled anesthetic. Most of the agents are rapidly eliminated from the body and donot cause post-operative respirtory depression.

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Primary Characteristics

Enflurane is also known as Methylflurether.

It belongs to General Anesthetics-Volatile pharmacological group on the basis of mechanism of action.

Molecular Weight: 184.5 · Solubility in Water: Slighlty soluble · Solubility in Alcohol: very slightly soluble · Non-proprietary name: Enflurane.

Pharmacokinetics

Distribution: Enflurane has a volume of distribution is 8.6 l/ kg. plasma protein binding is 50-60%.

Elimination: it is metabolised via Enflurane in metabolized by liver, plasma half-life is 11hours, renal excretion is 90% through urine.

Indications

Enflurane is primarily indicated in conditions like Induction and maintenance of anaesthesia, Reactive airways disease.

Enflurane is also indicated for secondary conditions like Obstetric anaesthesia, Obstetric pain.

Contraindications

Enflurane is contraindicated in conditions like Epilepsy, Renal diseases.

Dosage

Enflurane's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.75 %	1.75 %	—	Inhalation	Maintenance, As Required for Anaesthesia induction
3.25 %	3.25 %	—	Inhalation	Initially as Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown16 interactions

3 interactions

Moderate6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Enflurane in overdosage may give rise to further complications which include Bronchospasm , Bronchospasm , Asthmatic attack.

Enflurane produces potentially life-threatening effects which include Malignant hyperpyrexia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Enflurane are Depression of vital functions.

Enflurane is known to cause more or less tolerable side effects which are usually transient. These include Arrhythmia, Hiccough , Hypotension , Nausea, Respiratory depression, Shivering , Vomiting .

Warnings / Precautions

Enflurane should be used with caution in patients with convulsive disorder. Avoid use in patients having susceptibility to malignant hyperthermia. Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Patients with chronic disease such as diabetes or hypertension may require adjustment to their therapy before anesthesia. Anesthetics should be given with caution in patients with cardiac, respiratory, renal or hepatic impairment. It should be used with caution in elderly patients because they often have significantly decreased MACs and are more susceptible to anesthetic-induced hypotension and circulatory depression. It is classified as category B drug, it should be used with caution during pregnancy.

Interference in Pathology

Enflurane may interfere in the diagnosis of Measurement of the Nitrogen and Ox partial pressure by Polarographic & Mass Spectrometric Methods .

Available Brands

None recorded.

Storage Conditions

Enflurane should be stored . Inhalation Liq. Inj.

Drug Classification

1.1.1.2 — Inhalational anesthetics