Encainide (HCl)

Drug #275

Encainide (HCl) is antiarrhythmic agent. Encainide (HCl) is investigational drug. Encainide (HCl) is used to treat irregular heartbeats (arrhythmias) and maintain a normal heart rate.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Piperidyl Benzanilide.

It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.

Molecular Weight: 389 · Solubility in Water: freely soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Encainide (HCl).

Pharmacokinetics

Absorption: Encainide (HCl) has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 38.5% (±2.5%).

Distribution: Encainide (HCl) has a volume of distribution is 270 litre. plasma protein binding is 70%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 2.5-22 hr, renal excretion is 60%.

Indications

Encainide (HCl) is primarily indicated in conditions like Cardiac arrhythmia, Supraventricular arrhythmias, Ventricular arrhythmias.

Contraindications

Encainide (HCl) is contraindicated in conditions like Cardiogenic shock, Cardiac failure, Conduction system disease.

Dosage

Encainide (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.607 mg/kg	0.607 mg/kg	Every 8h	PO	Maintenance, As Required
25 mg	25 mg	Every 8h	PO	Initially for 1 Week (Usual dosage 100-200 mg/day)
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Encainide (HCl) in overdosage may give rise to further complications which include Sinoatrial block, Congestive heart failure .

Encainide (HCl) produces potentially life-threatening effects which include Arrhythmias. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Encainide (HCl) are AV block, Torsades de pointes, Asystole, Bradycardia, Hypotension, Cardiogenic shock.

Encainide (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Dizziness, Dyspnea, Headache, Insomnia, Metallic taste, Nausea, Tinnitus, Vomiting .

Warnings / Precautions

It should be used with caution in patients with a history of a myocardial infarction with left ventriuclar dysfunction because of an increased risk of arrhythmias. Electrolyte imbalances, such as hyperkalemia or hypokalemia, should be corrected before beginning therapy with any antiarrhythmic agent. It should be used with caution in patients with diabetes mellitus or pre-existing glucose-intolerance. Blood glucose monitioring is recommended. Encainide should be used with caution in patients with kidney or liver impairment, because hepatic impairment may reduced elimination rate of encainide which may lead to toxicity.

Interference in Pathology

Encainide (HCl) may interfere in the diagnosis of Serum glucose level.

Available Brands

None recorded.

Storage Conditions

Encainide (HCl) should be stored Caps.

Drug Classification

1.12.2 — Antiarrhythmic drugs