Edrophonium (Cl)

Also known as: Edrophonium

Drug #272

Edrophonium (Cl) is anticholinesterase agent and a quaternary amine. Edrophonium (Cl) is more rapidly absorbed and has a short duration of action than neostigmin. Edrophonium (Cl) is used in the diagnosis of myasthenia gravis.

← Previous drug Next drug →

Primary Characteristics

Edrophonium (Cl) is also known as Edrophonium .

It is of Synthetic origin and belongs to Alkylammonium Salt.

It belongs to Cholinestrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group. It is also classified under Antidotes .

Molecular Weight: 201.7 · Solubility in Water: very soluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Edrophonium (Cl).

Pharmacokinetics

Distribution: Edrophonium (Cl) has a volume of distribution is 1.1 l/kg.

Elimination: it is metabolised via in plasma & liver, plasma half-life is 1.8 hr.

Indications

Edrophonium (Cl) is primarily indicated in conditions like Androgen deficiency and male infertility, Cardiac arrhythmia, Diagnosis of dual block due to suxamethonium, Diagnosis of myasthenia gravis, Influenza A, Myasthenia gravis diagnosis, Neuromuscular blockade reversal, Succinylcholine-induced dual block diagnosis, Treatment of endometriosis.

Contraindications

Edrophonium (Cl) is contraindicated in conditions like Intestinal obstruction, Urinary obstruction.

Dosage

Edrophonium (Cl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 mg/kg	600 mg/kg	—		As Required
0.086 mg/kg	0.086 mg/kg	—	IV	As Required
Paediatric Dosage (20kg)
0.1 mg/kg	0.1 mg/kg	—	Intra Venous	Once in divided doses
Neonatal Dosage (3kg)
0.1 mg/kg	0.1 mg/kg	—	Slow intravenous	Single dose

Drug Interactions

Unknown7 interactions

1 interaction

Major1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Edrophonium (Cl) in overdosage may give rise to further complications which include Increased airway resistance , AV-block , Cardiac arrhythmias, Sinus bradycardia .

Edrophonium (Cl) produces potentially life-threatening effects which include Neuromuscular blockage, Cardiac Arrest . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Edrophonium (Cl) are Bronchospasm, GI hypermotility, Cardiac arrhythmias, Perspiration , Visual distrubances, Hypotension, Respiratory failure, Bradycardia.

Edrophonium (Cl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Allergic reactions, Blurred vision, Diarrhea, Lacrimation, Leg cramps, Lingual fasciculation, Nausea, Periocular fasciculation, Perioral fasciculation, Prostatism, Salivation , Vomiting .

Warnings / Precautions

Edrophonium should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, in thyroid disorders, intestinal disorders, peptic ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. It is classified as pregnancy category C and should be used only if clearly needed during pregnancy.

Interference in Pathology

Edrophonium (Cl) may interfere in the diagnosis of None well documented.

Available Brands

None recorded.

Storage Conditions

Edrophonium (Cl) should be stored Inj.

Drug Classification

1.4.2.11 — Miscellaneous
2.20 — Muscle relaxants and cholinesterase inhibitors