Dothiepin (HCl)
Also known as: Dosulepin (HCl)
Dothiepin (HCl) is antidepressant drug and is used to treat depression.
Primary Characteristics
Dothiepin (HCl) is also known as Dosulepin (HCl).
It is of Synthetic origin and belongs to Amitryptyline.
It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Tricyclin (Tertiary Amine) pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 331.9 · pKa: 8.5 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 8 · Non-proprietary name: Dothiepin (HCl).
Pharmacokinetics
Absorption: Dothiepin (HCl) has an oral bioavailability is 95%.
Distribution: Dothiepin (HCl) has a volume of distribution is 45 l/kg. plasma protein binding is 80-90%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 22 hr, renal excretion is 55%.
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Indications
Dothiepin (HCl) is primarily indicated in conditions like Anxiety, Cytotoxic chemotherapy, Depression, Depressive illness, Nausea, vomiting (acute attacks), Sedation.
Contraindications
Dothiepin (HCl) is contraindicated in conditions like Cardiac arrhythmia, Mania, Myocardial infarction, Heart block, Liver diseases, Narrow-angle glaucoma, Prostate disease.
Dosage
Dothiepin (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 62.5 mg | 62.5 mg | Every 24h | PO | Elderly 75mg may be significant |
| 112.5 mg | 112.5 mg | Every 24h | PO | Initially at night, increased gradually |
| 225 mg | 225 mg | Every 24h | PO | Elderly 225 mg hospital use, 1 or 2 divided doses. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group , Child not recomended | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dothiepin (HCl) in overdosage may give rise to further complications which include Convulsions , Cholestatic jaundice , Cholestatic jaundice , Hypomania , Mania , Paranoid delusions .
Dothiepin (HCl) produces potentially life-threatening effects which include Bone marrow suppression, Agranulocytosis. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Dothiepin (HCl) are Convulsions , Drowsiness, Cardiac dysrhythmias, Blurred vision, Drowsiness, Dry mouth, Unconsciousness, Respiratory depression, Hallucinations , Respiratory depression, Tremor, Excitation , Respiratory depression.
Dothiepin (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Accomodation disturbances, Blurred vision, Confusion, Constipation , Diarrhea, Dizziness, Drowsiness, Dry mouth, ECG changes, Hyponatremia, Irritability, Nausea, Photosensitivity, Postural hypotension, Skin RashX, Sleep disturbance, Sweating , Tachycardia, Taste disturbance, Tinnitus, Tremor, Urinary retention, Urticaria, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression
Manufacturers
Manufacturers of Dothiepin (HCl) in Pakistan: