Domperidone - Drug Monograph | DrugInfoSys ODIS

Primary Characteristics

It is of Synthetic origin and belongs to Benzimidazolin.

It is also classified under Antiemetic/Antivertigo Agents .

Molecular Weight: 425.9 · pK_a: 7.9 · Solubility in Water: 1 in 50000 · Solubility in Alcohol: 1 in 400 · Non-proprietary name: Domperidone.

Pharmacokinetics

Absorption: Domperidone has an oral bioavailability is 69.75% (±23.25%), pre-systemic (first-pass) metabolism accounts for 43.5% (±41.5%).

Distribution: Domperidone has a volume of distribution is 5.7 l/kg. plasma protein binding is 91-93%.

Elimination: it is metabolised via extensively by liver & Gut, plasma half-life is 12-16 hr (oral), 7.5 hr (parentral), renal excretion is major 31% and 66% in feces.

Indications

Domperidone is primarily indicated in conditions like Acute nausea and vomiting, Delayed gastric emptying, Dyspepsia, Functional dyspepsia, Gastric distension pain due to pressure on the stomach, Gastro-oesophageal reflux disease, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (L-dopa induced), Non-ulcer dyspepsia, Reflux oesophagitis.

Domperidone is also indicated for secondary conditions like Cytotoxic chemotherapy, Heart burn, Lactation.

Contraindications

Domperidone is contraindicated in conditions like Allergy, Hepatic impairment, Serious resistant GI mycoses.

Dosage

Domperidone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 6h	PO	15-30 minutes before meal. It can be used for maximum 12 weeks. To a maximum dose of 80mg.
30 – 60 mg	—	Every 6h	Suppository
Paediatric Dosage (20kg)
500 ug/kg	500 ug/kg	Every 8h	Oral	15-30 minutes before meal. It can be used for maximum 12 weeks. To a total daily dose of 80mg.
30 – 120 mg	—	Every 8h	Suppository
Neonatal Dosage (3kg)
0.3 mg/kg	0.3 mg/kg	Every 8h	Oral	-

Drug Interactions

Unknown3 interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Domperidone in overdosage may give rise to further complications which include Parkinsonism , Extrapyramidal dystonic reactions , Tardive dyskinesia .

Domperidone produces potentially life-threatening effects which include Seizures , Dysrhythmias. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Domperidone are Convulsions , Coma, GI disturbances, Extrapyramidal effects .

Domperidone is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Breast enlargement, Diarrhea, Drowsiness, Dry mouth, Galactorrhea, Headache, Hyperprolactinemia, Insomnia, Itching, nervousness, Reduced libido, Restlessness, Skin rashes, Soreness , Thirst.

Warnings / Precautions

Domperidone should be used with great caution if given intravaneously, because of the risk of arrhythmias, especially to patients predisposed to cardiac arrhythmias or hypokalaemia.

Interference in Pathology

Domperidone may interfere in the diagnosis of Not well documented.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

5 mg/ml

Susp

1 mg/ml 10 mg/5ml 100 mg/5ml 120 mg/5ml 5 mg/5ml

Syrup

5 mg/5ml

Tabs

1 mg 10 mg 12.72 mg 15 mg 19.1 mg 30 mg 5 mg

Vag Tabs

10 mg

Multi-Ingredient Combinations

Syrup

5 mg

Tabs

15 mg 19.1 mg

Storage Conditions

Domperidone should be stored Tab.

Drug Classification

1.17.2 — Antiemetics & antinauseants