Dobutamine (HCl)
Dobutamine is a synthetic, direct acting catecholamine that is a ß1 receptor agonist. Dobutamine (HCl) is available as racemic mixture. Chemically it resembles dopamine. It provides additional pumping strength by stimulating the heart muscle and effective to treat low output acute heart failure
Primary Characteristics
It is of Synthetic origin and belongs to Catecholamine.
It belongs to Alpha & Beta adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Adrenergic Agonist Agent pharmacological group. It is also classified under Drugs used in Shock .
Molecular Weight: 337.8 · pKa: 9.5 · Solubility in Water: very low · Solubility in Alcohol: very low · Non-proprietary name: Dobutamine (HCl).
Pharmacokinetics
Distribution: Dobutamine (HCl) has a volume of distribution is 0.20 ± 0.08 l/kg.
Elimination: it is metabolised via extensive by liver, plasma half-life is 2 min, renal excretion is major.
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Indications
Dobutamine (HCl) is primarily indicated in conditions like Acid reflux disease (long-term management), Cardiac surgery, Cardiogenic shock, Cardiomyopathies, Heart failure, Hypotensive shock, Inotropic support in infarction, Septic shock.
Dobutamine (HCl) is also indicated for secondary conditions like Positive end expiratory pressure ventilation.
Contraindications
Dobutamine (HCl) is contraindicated in conditions like Obstructive cardiomyopathy, Constrictive pericarditis, Low cardiac filling pressure, Cardiac temponade, Ventricular arrhythmias.
Dosage
Dobutamine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2.5 – 10 mcg/kg/min | — | — | IV Inf | As Required |
| Paediatric Dosage (20kg) | ||||
| 2.15 – 20 mcg/kg/min | — | — | as required | |
| 5 mcg/kg/min | 5 mcg/kg/min | — | as reqiured. | |
| Neonatal Dosage (3kg) | ||||
| 8.75 ug/kg.min | 8.75 ug/kg.min | — | Infusion | As required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dobutamine (HCl) in overdosage may give rise to further complications which include Tissue necrosis .
Dobutamine (HCl) produces potentially life-threatening effects which include Myocardial Ischemia , Tachycardia, Cardiac arrhythmias, Hypertension, Hypotension, Myocardial ischemia, Extravasation. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Dobutamine (HCl) are Hypertension, Peripheral vasoconstriction, Myocardial ischemia, Arrhythmias.
Dobutamine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Breathlessness , Bronchospasm, Chest pain, Fatigue, Headache, Nausea, Non-specific chest pain, Palpitation, Paresthesias, Reaction at injection site, Vomiting .
Warnings / Precautions
Interference in Pathology
Dobutamine (HCl) may interfere in the diagnosis of Reduction in serum potassium concentration.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.12.4 — Drugs used in heart failure