Dithranol

Drug #258

Dithrano used to treat skin diseases such as psoriasis, eczema and chronic dermatoses.

Primary Characteristics

It is of Synthetic origin and belongs to Anthracenone.

It is also classified under Dermatological Products .

Molecular Weight: 226.2 · pK_a: 9.4 · Solubility in Water: Almost Insoluble · Solubility in Alcohol: Slight · Non-proprietary name: Dithranol.

Pharmacokinetics

Elimination: it is metabolised via via Skin, renal excretion is major.

Indications

Dithranol is primarily indicated in conditions like Psoriasis.

Contraindications

Dithranol is contraindicated in conditions like Inflammatory psoriasis, Facial psoriasis, Pustular psoriasis.

Dosage

Dithranol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 %	5 %	—	Topical	As Required for 2-3 Weeks
Paediatric Dosage (20kg)
0.15 %	0.15 %	—	Topical	As Required
Neonatal Dosage (3kg)
0.15 %	0.15 %	—	Topical	As Required

Drug Interactions

None recorded.

Side Effects

Dithranol in overdosage may give rise to further complications which include Severe inflammation , Irritation , Contact dermatitis .

Dithranol is known to cause more or less tolerable side effects which are usually transient. These include Hair loss, Local burning, Purple brown staining of skin, Sensation of warmth, Staining of skin & clothes.

Warnings / Precautions

Dithranol should not be used for acute psoriasis or on inflamed skin. Its use on face, skin flexures and genitals should be avoided. Avoid use hear eyes and sensitive areas of skin.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Oint

0.35 %w/w

Storage Conditions

Dithranol should be stored Cream, Oint, Paste.

Drug Classification

1.13.5.2 — Others

Manufacturers

Manufacturers of Dithranol in Pakistan:

Seignior