Distigmine (Br)

Also known as: Bispyridostigmine Br

Drug #256

Distigmine (Br) used in the prevention and treatment of post-operative gastro-intestinal atony and in post-operative urinary retention. Anti biotic (aunoglycoside,tetracycling,polymycin)

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Primary Characteristics

Distigmine (Br) is also known as Bispyridostigmine Br.

It is of Synthetic origin and belongs to Carbamoyldipyridine Queutenergy Ammonium compound.

It belongs to Cholinestrase inhibitor pharmacological group on the basis of mechanism of action.

Molecular Weight: 576.3 · pK_a: 12.0 · Solubility in Water: > 1 in 10 · Solubility in Alcohol: low · Non-proprietary name: Distigmine (Br).

Pharmacokinetics

Elimination: it is metabolised via by Plasma (estrases), renal excretion is 1-2%.

Indications

Distigmine (Br) is primarily indicated in conditions like Intestinal atony, Neurogenic bladder, Postoperative ileus, Postoperative urinary retention, Prophylaxis of NSAID-associated gastric or duodenal ulcer.

Distigmine (Br) is also indicated for secondary conditions like Extravasation/haematoma, Myasthenia gravis.

Contraindications

Distigmine (Br) is contraindicated in conditions like Circulatory insufficiency, GI obstruction, Urinary outflow obstruction.

Dosage

Distigmine (Br)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 – 20 mg	—	Every 24h	IM	Before break fact (increased at internals of 3-4 days)
0.5 mg	0.5 mg	Every 24h	IM	Percentral (24 to 72 hours after surgury and repeated at intervals of 1 to 3 days)
Paediatric Dosage (20kg)
10 mg	10 mg	—		daily
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown15 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Distigmine (Br) in overdosage may give rise to further complications which include AV-block , Bronchospasm , Cholinergic crises , Sinus bradycardia , Dyspnea.

Distigmine (Br) produces potentially life-threatening effects which include Coma, Bradycardia , Convulsions , Neuromuscular blockage, Hypotension, Hypoxemia , Paralysis , Bronchoconstriction, Severe muscle weakness. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Distigmine (Br) are Increased peristalsis, Retching, Spasticity, Nausea, Pallor, Paralysis , Sweating .

Distigmine (Br) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Diarrhea, Miosis , Salivation , SweatingX, Urinary urgency.

Warnings / Precautions

Distigmine should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. It should be used only if clearly needed during pregnancy.

Available Brands

None recorded.

Storage Conditions

Distigmine (Br) should be stored Tab.

Drug Classification

1.20 — Muscle relaxants and cholinesterase inhibitors