Disopyramide

Drug #255

Disopyramide is a sodium channel blocking agent. Disopyramide is used as an antiarrythmic agent. Disopyramide is a class IA drug and shows similar action to that of quinidine and procainamide.

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Primary Characteristics

It is of Synthetic origin and belongs to Pyridineacetamide.

It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 339.5 · pK_a: 8.4 · Solubility in Water: Slightly · Solubility in Alcohol: Soluble · Non-proprietary name: Disopyramide.

Pharmacokinetics

Absorption: Disopyramide has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 12.5% (±2.5%).

Distribution: Disopyramide has a volume of distribution is 0.7 l/kg. plasma protein binding is 50-65%.

Elimination: it is metabolised via 30%, plasma half-life is 4-10 hr, renal excretion is 40-60%.

Indications

Disopyramide is primarily indicated in conditions like Arrhythmias following surgical procedures, Conversion of atrial fibrillation, Digitalis induced arrythmias, Duodenal ulceration, Hypertrophic cardiomyopathy, Premature systoles, Supraventricular tachycardia, Tobacco amblyopia and leber's optic atrophy, Ventricular tachycardia, Wolf-parkinson-white syndrome.

Contraindications

Disopyramide is contraindicated in conditions like Cardiogenic shock, Hypotension, Left ventricular failure, Digitalis toxicity, Second or third degree A-V block.

Dosage

Disopyramide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 mg/kg	2 mg/kg	—	IV Inf	Over 5-15 min. To maximum of 150mg followed by 200mg orally
300 – 800 mg	—	—	PO	Individed doses
Paediatric Dosage (20kg)
5 mg/kg	5 mg/kg	Every 6h	Oral	-
Neonatal Dosage (3kg)
5 mg/kg	5 mg/kg	Every 6h	oral

Drug Interactions

Unknown24 interactions

8 interactions

Major5 interactions

Moderate7 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Disopyramide in overdosage may give rise to further complications which include Glaucoma , Jaundice , Jaundice , Urinary retention, Myasthenia gravis , Urinary retention.

Disopyramide produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia, Negative ionotropic effects, QRS widening, QT prolongation, Torsades de pointes, Hypoglycemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Disopyramide are Bradycardia, Cardiac arrhythmias, Apnea, ECG alterations, Unconsciousness, Asystole, Ventricular fibrillation.

Disopyramide is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Blurred vision, Constipation , Dry mouth, Fatigue, Headache, Skin rash, Sweating , Weight gain, Xerosis, Xerostomia .

Warnings / Precautions

Reduce doses of disopyramide in case of kidney or liver impairment, carefully monitor ECG. Correct any potassium deficit before initiating therapy because disopyramide may be ineffective in hypokalemia or its toxicity is enhanced in hyperkalemia. It should be used with caution in patient with diabetes mellitus. It is classified as pregnancy category C and use of disopyramide should be avoided during pregnancy unless the potential benefit justifies the risk to the fetus.

Available Brands

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Single Ingredient

Caps

100 mg

Storage Conditions

Disopyramide should be stored Caps.

Drug Classification

1.12.2 — Antiarrhythmic drugs

Manufacturers

Manufacturers of Disopyramide in Pakistan:

Searle