Disodium Edetate (Dihydrate)

Also known as: EDTA, Endrate, Sodium Edetate

Drug #254

Disodium Edetate (Dihydrate) is used in emergency treatment of hypercalcemia and to control digitalis induced cardiac arrhythmias.

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Primary Characteristics

Disodium Edetate (Dihydrate) is also known as EDTA, Endrate, Sodium Edetate, Edathanil disodium.

It is of Combo1 origin.

It is classified in Chelating Agent pharmacological group.

Non-proprietary name: Combo1.

Molecular structure of Disodium Edetate (Dihydrate)

Pharmacokinetics

None recorded.

Indications

Disodium Edetate (Dihydrate) is primarily indicated in conditions like Calcified corneal opacity, Cardiac glycoside-induced arrhythmia, Hypercalcaemia.

Contraindications

Disodium Edetate (Dihydrate) is contraindicated in conditions like Renal diseases.

Dosage

Disodium Edetate (Dihydrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
70 mg/kg.min	70 mg/kg.min	—	IV Inf	For 2-3 Hours for 5 Days
Paediatric Dosage (20kg)
55 mg/kg	55 mg/kg	Every 24h	Infusion	Infuse over 3 or more hrs
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Disodium Edetate (Dihydrate) in overdosage may give rise to further complications which include Renal tubular changes , Engorgement of reticuloendothelial cells , Coarse eosinophilic granules, Hemorrhage.

Disodium Edetate (Dihydrate) produces potentially life-threatening effects which include Convulsions , Arrhythmias, Cardiac Arrest , Cardiac arrest, Hypocalcemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Disodium Edetate (Dihydrate) are Increased level of insulin.

Disodium Edetate (Dihydrate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramping pain, Chills, Dermatitis, Diarrhea, Fatigue, Fever, Hypotension , Local burning, Nausea, Paresthesias, Reaction at injection site, Respiratory arrest, Tetany, Weakness.

Warnings / Precautions

Disodium edetate should be used with caution in patients with limited cardiac reverse or congestive heart failure. After infusion, have patients remain supine for short period of time, because there is a possibility of postural hypotension. The cardiac status of the patient should be determined before administering edetate disodium. The drugs negative inotropic effects could adversely affect a patient with cardiac disease. It should be used with caution in patients with a potassium deficiency. Edetate disodium is not recommended for use in patients with calcified tubercular lesions which that have healed or in patients with active tuberculosis.Because edetate disodium chelates and reduces serum calcium, it should not be used in patientswith hypocalcemia or in patients with normal serum calcium values. Edetate disodium is classified as pregnancy category C. It should be used with caution during pregnancy only if the potential benefit outweighs the risk to the fetus.

Interference in Pathology

Disodium Edetate (Dihydrate) may interfere in the diagnosis of Urinanalysis , Periodic BUN and creatinine determinations.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Eye Drops

0.1 %w/v

Soln

0.05 g/L

Storage Conditions

Disodium Edetate (Dihydrate) should be stored Inf .

Drug Classification

1.12.2 — Antiarrhythmic drugs

Manufacturers

Manufacturers of Disodium Edetate (Dihydrate) in Pakistan:

Schazoo Usmanco