Dipyridamole

Drug #253

Dipyridamole is 2, 6-Bis (diethanolamino)-4, 8-dipiperidinopyrimido- (5, 4-d) pyrimidine. Dipyridamole is a platelet aggregation inhibitor. It prevents the blood cells from clumping together and keeps the blood flow smooth.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Piperidinopyrimidine.

It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antiplatelet Agent pharmacological group. It is also classified under Hematological Agents .

Molecular Weight: 504.6 · pK_a: 6.4 · Solubility in Water: Insoluble in water · Solubility in Alcohol: soluble · Non-proprietary name: Dipyridamole.

Pharmacokinetics

Absorption: Dipyridamole has an oral bioavailability is 57.5% (±30.5%).

Distribution: Dipyridamole has a volume of distribution is 2 l/kg. plasma protein binding is > 99%.

Elimination: it is metabolised via Hepatic, plasma half-life is 11.6 ± 2.2 hr, renal excretion is 1-3%.

Indications

Dipyridamole is primarily indicated in conditions like Ischemic stroke prophylaxis, Secondary prevention of ischaemic stroke and tias, Transient ischemic attacks prophylaxis.

Dipyridamole is also indicated for secondary conditions like Analgesia and suppression of respiratory activity.

Contraindications

Dipyridamole is contraindicated in conditions like Bleeding disorders.

Dosage

Dipyridamole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
200 mg	200 mg	Every 6h	PO	Secondary prevention of stroke and iscaamic attack.
450 mg	450 mg	—	PO	Divided doses before meals. Prophylaxis of thromboembolism.
Paediatric Dosage (20kg)
5 mg/kg	5 mg/kg	Every 6h	Oral
Neonatal Dosage (3kg)
1.25 mg/kg	1.25 mg/kg	Every 6h	Oral	-

Drug Interactions

Unknown10 interactions

7 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dipyridamole in overdosage may give rise to further complications which include Angina .

Dipyridamole produces potentially life-threatening effects which include Hemorrhage , Coronary steel, Hemorrhage. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Dipyridamole are Flushing.

Dipyridamole is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Facial flushing, Fainting, GI disturbance, Headache, Nausea, Pruritus , Skin rash, Syncope , Vomiting , Weakness.

Warnings / Precautions

Dipyridamole should not be used in patients with hypotension unstable angina, aorticstenosis, recent myolar dial infarction because it will produced peripheral vasodilation. It should be used with caution in patient with asthma. It is classified as pregnancy category B and should be used with caution in pregnancy only if clearly needed.

Interference in Pathology

Dipyridamole may interfere in the diagnosis of Laboratory tests involving fluorescence or nephelometry measurements .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

5 mg/ml

Tabs

100 mg 25 mg

Storage Conditions

Dipyridamole should be stored Inj. Tab.

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators

Manufacturers

Manufacturers of Dipyridamole in Pakistan:

Merck Zafa