Dinoprostone

Drug #249

Dinoprostone is a prostaglandin E2 (PGE2). Dinoprostone is used as an oxytocic for induction of abortions or in miscarriages and certain conditions of the womb (uterus).

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Primary Characteristics

It is of Synthetic origin and belongs to PG-Heptenoic Acid.

It belongs to PGE-II agonis pharmacological group on the basis of mechanism of action and also classified in Abortifacients pharmacological group.

Molecular Weight: 352.48 · pK_a: 4.9 · Solubility in Water: 1 in 1000 · Solubility in Alcohol: high · Non-proprietary name: Dinoprostone.

Pharmacokinetics

Elimination: it is metabolised via 95% via lungs, plasma half-life is 2.5-5 min, renal excretion is major.

Indications

Dinoprostone is primarily indicated in conditions like Abortion, Hydatidiform mole, Labor induction, Uterine atonia.

Contraindications

Dinoprostone is contraindicated in conditions like Asthma, Glucoma, Hepatic disease, Pulmonary disease, Pelvic inflammatory disease.

Dosage

Dinoprostone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 ug	500 ug	—	Intra Cervical	As Required
3 mg	3 mg	—	Intra Vaginal	A 2nd tab. may be inserted after 6-8 hrs. If labour is not established.
Paediatric Dosage (20kg)
0 – 0	—	—		Not applicable in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dinoprostone in overdosage may give rise to further complications which include Severe pain , Acute fetal distress .

Dinoprostone produces potentially life-threatening effects which include Cardiogenic collapse. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Dinoprostone are Uterine hypertonus.

Dinoprostone is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Erythema, Flushing, Nausea, Pallor, Syncope , Transient pyrexia, Vaginal burning, Vomiting .

Warnings / Precautions

Dinoprostone should be used with caution in patients with medical history, including any allergy (especially drug allergy), pelvic infections, heart, lungs, kidney or liver diseases, high or low blood pressure, anemia, cervicitis, diabetes mellitus, acute vaginitis, infected endocervical lesions, compromised uterus, or a history of asthma, hypertension, hypotension, epilepsy or other seizure disorder, or jaundice. It should not be used at term if patient have a history of caesarean section or major surgery, in patient with vasa previa or who have had unexplained vaginal bleeding during their course of pregnancy. It should not be used in case of abnormal fetal position, cephalopelvic disproportion or signs of fetal distress. Maternal problems such as a history of difficult labor or traumatic delivery, grand multiparity, or any hyperactive or hypertonic uterine patterns indicate that dinoprostone should not be used.

Interference in Pathology

Dinoprostone may interfere in the diagnosis of UCG test.

Available Brands

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Single Ingredient

Gel

Inj

Tabs

Vag Tabs

Storage Conditions

Dinoprostone should be stored Vag Suppositoties.

Drug Classification

1.22.1.1 — Oxytocics

Manufacturers

Manufacturers of Dinoprostone in Pakistan:

Hansel Himont Pharma Nabiqasim Pfizer Platinum Wilsons