Dinoprost

Also known as: Prostaglandin F2Alfa

Drug #248

Dinoprost is a natural oxytocic protaglandin. Dinoprost is a synthetic derivative of itone in which the O atom in 9-position of the latter is reduced to OH. Dinoprost is effective as an abortifacient i.e., causing abortion.

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Primary Characteristics

Dinoprost is also known as Prostaglandin F2Alfa.

It is of Natural origin and belongs to PG-Heptenoic Acid.

It belongs to PGF-II alpha-agonist pharmacological group on the basis of mechanism of action and also classified in Prostaglandin pharmacological group.

Molecular Weight: 354.5 · pK_a: 5.6 · Solubility in Water: low · Solubility in Alcohol: high · Non-proprietary name: Dinoprost.

Pharmacokinetics

Elimination: it is metabolised via Predominent in Lungs, plasma half-life is 30 sec, renal excretion is major.

Indications

Dinoprost is primarily indicated in conditions like Abortion, Haemorrhage, Hydatidiform mole, Labor induction.

Contraindications

Dinoprost is contraindicated in conditions like Asthma, Glucoma, Pelvic infections.

Dosage

Dinoprost's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
4 – 10 mg	—	—	Intra Mniotically	A 2nd tab. may be inserted after 6-8 hrs. If labour is not established. By slowly injection 8 ml of sodium containing 5mg/ml.
Paediatric Dosage (20kg)
0 – 0	—	—		Not applicable in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dinoprost in overdosage may give rise to further complications which include Intravascular coagulation.

Dinoprost produces potentially life-threatening effects which include Cardiogenic collapse. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Dinoprost are Collapse, Severe GI symptoms.

Dinoprost is known to cause more or less tolerable side effects which are usually transient. These include bronchoconstriction, Bronchospasm, Diarrhea, dizziness, Flushing, Headache, Nausea, Pyrexia , Shivering , Vomiting , Wheezing .

Warnings / Precautions

Dinoprost should be used with caution in patients with medical history, including any allergy (especially drug allergy), pelvic infections, heart, lungs, kidney or liver diseases, asthma, high or low blood pressure, anemia, diabetes, seizure disorder, infections in the vaginal area. This medication should be used only when clearly needed during pregnancy or lactation.

Available Brands

None recorded.

Storage Conditions

Dinoprost should be stored Inj.

Drug Classification

1.22.1.1 — Oxytocics