Diflunisal

Drug #239

Diflunisal is a newer NSAID (non-steroidal anti-inflammatory drug) chemically derived from salicyclic acid. It relieves pain and reduces inflammation. Diflunisal is commonly used to treat pain, swelling and stiffness associated with arthritis.

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Primary Characteristics

It is of Synthetic origin and belongs to Salicylic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 250.2 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Diflunisal.

Pharmacokinetics

Absorption: Diflunisal has an oral bioavailability is 94% (±4%).

Distribution: Diflunisal has a volume of distribution is 7.5 litre. plasma protein binding is 99%.

Elimination: it is metabolised via extensive, hepatic, plasma half-life is 10.8 hr (8-12 hr), renal excretion is 80-95%.

Indications

Diflunisal is primarily indicated in conditions like Dental surgery, Dysmenorrhoea, Mild to moderate pain, Osteoarthritis, Pain, Rheumatoid arthritis, Sprains, Strains.

Contraindications

Diflunisal is contraindicated in conditions like Peptic ulcer, Bronchospasm, Renal diseases.

Dosage

Diflunisal's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5.357 mg/kg	5.357 mg/kg	Every 12h	PO	Maintenance, As Required
7.143 mg/kg	7.143 mg/kg	—	PO	Initially for Once
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown10 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Diflunisal in overdosage may give rise to further complications which include Stevens johnson syndrome , Jaundice , Gi bleeding , Renal failure , Gastric ulceration , Acute interstitial nephritis .

Diflunisal is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, GI symptoms, Headache, Tinnitus.

Warnings / Precautions

Diflunisal should be used with caution and lower daily dose in patients with kidney impairment. It should be used with caution in patients with compromised cardiac function, hypertension and other conditions pre-disposing to fluid retension.

Interference in Pathology

Diflunisal may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

250 mg 500 mg

Storage Conditions

Diflunisal should be stored Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers

Manufacturers of Diflunisal in Pakistan:

Genome