Diethylpropion (HCl)

Drug #238

Diethylpropion (HCl) is anorectic agent. Diethylpropion (HCl) is used as an appetite suppressant in conjunction with diet plan to reduce weight.

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Primary Characteristics

It is of Synthetic origin and belongs to Propiophenon.

It belongs to Anorectic Agent pharmacological group on the basis of mechanism of action and also classified in Obesity pharmacological group.

Molecular Weight: 241.8 · Solubility in Water: 1 in 0.5 · Solubility in Alcohol: 1 in 3 · Non-proprietary name: Diethylpropion (HCl).

Molecular structure of Diethylpropion (HCl)

Pharmacokinetics

Absorption: Diethylpropion (HCl) has an oral bioavailability is 96.5% (±1.5%).

Elimination: it is metabolised via extensive, plasma half-life is 1.5-2 hr, renal excretion is 90%.

Indications

Diethylpropion (HCl) is primarily indicated in conditions like Obesity.

Contraindications

Diethylpropion (HCl) is contraindicated in conditions like Glucoma, Hypertension, Hyperthyroidism, Psychosis, Pulmonary hypertension, Arteriosclerosis, Cardiopathy.

Dosage

Diethylpropion (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg	25 mg	Every 8h	PO	1 hr before meals in mid morning.
75 mg	75 mg	Every 24h	PO	As a modified released preparation.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Diethylpropion (HCl) in overdosage may give rise to further complications which include Psychosis , Depression , Unstable personality , Psychological dependence.

Diethylpropion (HCl) produces potentially life-threatening effects which include Cardiac arrhythmias, Pulmonary hypertension. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Diethylpropion (HCl) are Tachycardia , Confusion , Tachypnea, Mydriasis, Agitation, Delusions , Unstable blood pressure.

Diethylpropion (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Allergic reactions, Constipation , Depression, Diarrhea, dizziness, Drowsiness, Dry mouth, Gynecomastia, Increased precordial pain, Insomnia, Nausea, Nervousness, SweatingX, Vomiting .

Warnings / Precautions

Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness, extreme fatigue and depression. Diethylpropion should be used with caution and monitor blood pressure in patient with mild hypertension. Dose titration and dose discontinuance may be necessary in epileptic patients.

Available Brands

None recorded.

Storage Conditions

Diethylpropion (HCl) should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression