Dicobalt Edetate

Drug #234

Dicobalt Edetate is used as an antidote for cyanide poisoning.

Primary Characteristics

It is of Synthetic origin and belongs to Cobalt Chelate.

It is classified in Chelating Agent pharmacological group.

Molecular Weight: 406.1 · Solubility in Water: high · Solubility in Alcohol: poor · Non-proprietary name: Dicobalt Edetate · pH: 5.7.

Pharmacokinetics

Distribution: Dicobalt Edetate has a plasma protein binding is low.

Elimination: plasma half-life is short, renal excretion is entire.

Indications

Dicobalt Edetate is primarily indicated in conditions like Cyanide poisoning.

Contraindications

Dicobalt Edetate is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Dicobalt Edetate 's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
300 mg	300 mg	—	IV	Over 7 minutes.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Dicobalt Edetate in overdosage may give rise to further complications which include Vasodilation , Severe drop in BP, Angina .

Dicobalt Edetate produces potentially life-threatening effects which include Anaphylactoid reactions , Convulsions , Collapse , Facial edema, Gross edema of pharynx, Neck edema. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Dicobalt Edetate are Hypovolemia.

Dicobalt Edetate is known to cause more or less tolerable side effects which are usually transient. These include Coarse tremor of fingers, Facial flushing, Flushing, Headache, Nausea, Nervousness, Restlessness, Sweating , Vomiting .

Warnings / Precautions

The adverse effect of Dicobalt Edetate is severe in the absence of cyanide, therefore it should not be administered unless cyanide poisoning is confirmed and poisoning is moderate or severe, i.e.,when conciousness is impaired.

Available Brands

None recorded.

Storage Conditions

Dicobalt Edetate should be stored IV Inj.

Drug Classification

1.4.2.7 — Cyanide poisoning