Eltrombopag Olamine
Eltrombopag olamineis an antihemorrhagic dug. It is a small molecule thrombopoietin (TPO) receptor agonist for oral administration. Eltrombopag interacts with the transmembrane domain of the TPO receptor (also known as cMpl) leading to increased platelet production. The chemical name for eltrombopag olamine is 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4- ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid - 2-aminoethanol (1:2).
Primary Characteristics
It is of Synthetic origin and belongs to biphenyl hydrazone.
Molecular Weight: 564.65 · Solubility in Water: springly soluble · Non-proprietary name: Eltrombopag Olamine.
Pharmacokinetics
Distribution: Eltrombopag Olamine has a plasma protein binding is more than 99.9%.
Elimination: it is metabolised via hepatic, plasma half-life is 21-32hrs, renal excretion is 31% urine, 59% feces.
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Indications
Eltrombopag Olamine is primarily indicated in conditions like Idiopathic thrombocytopenic purpura.
Contraindications
None recorded.
Dosage
None recorded.
Drug Interactions
None recorded.
Side Effects
Eltrombopag Olamine in overdosage may give rise to further complications which include Hemorrhage.
Eltrombopag Olamine is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Asthenia , Back pain, Bone pain, Cataract, conjunctival hemorhage, Cough , Depression, Diarrhoea, dizziness, Dry eye, Dry skin, Dryness of eye, Dysgeusia, dyspepsia, Dyspnea, Ecchymoses, Erythema, Headache, Hyperbilirubinemia, Hyperhidrosis , increased ALT/AST, Insomnia, Jaundice , Menorrhagia , muscle spasm, Musculoskeletal pain , Myalgia, Nausea, Oedema, Palpitation, Paresthesias, Pruritis, Rash, Skin lesion, Thrombocytopenia, Vertigo, Vomiting .
Warnings / Precautions
Interference in Pathology
Eltrombopag Olamine may interfere in the diagnosis of Complete blood cell count.
Available Brands
Drug Classification
- 1.10.2 — Anticoagulants/Platelet deaggregators
Manufacturers
Manufacturers of Eltrombopag Olamine in Pakistan: