Pitavastatin
Pitavastatin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (or statin), is a lipid regulating drug with similar properties to simvastatin. It is used as the calcium salt in the treatment of hyperlipidaemias. The chemical name for pitavastatin is (+)monocalcium bis{(3R, 5S, 6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5 dihydroxy-6-heptenoate}
Primary Characteristics
It is of Synthetic origin and belongs to Statin.
It belongs to HMG-CoA Reductase inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 880.98 · Solubility in Water: very slightly · Solubility in Alcohol: slightly soluble · Non-proprietary name: Pitavastatin.
Pharmacokinetics
Absorption: Pitavastatin has an oral bioavailability is 51%.
Distribution: Pitavastatin has a volume of distribution is approximately 148 L. plasma protein binding is more than 97%-98%.
Elimination: it is metabolised via hepatuc, plasma half-life is approx. 12 hrs, renal excretion is 15% by urine, 79%by feces.
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Indications
Pitavastatin is primarily indicated in conditions like Dyslipidaemia, Hyperlipidaemia.
Contraindications
None recorded.
Dosage
Pitavastatin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 mg | 1.5 mg | — | PO | Dosage in Patients with Renal Impairment |
| 3 mg | 3 mg | — | PO | at any time of the day with or without food |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Pitavastatin is known to cause more or less tolerable side effects which are usually transient. These include Back pain, Constipation , Diarrhea, Myalgia, Pain in upper & lower extremities.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.12.6 — Lipid-regulating drugs /Anti-atheromas
Manufacturers
Manufacturers of Pitavastatin in Pakistan: