Lactitol Monohydrate

Drug #2283

Lactitol is synthetic disaccharide osmotic laxatives and analogue of lactulose. With its more pleasant taste, lactitol is better tolerated and morepalatable. Lactitol monohydrate is used as an oral powder or solution in the management of hepatic encephalopathy and in constipation.

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Primary Characteristics

It is of Synthetic origin and belongs to Lactulose(disacchride analogue).

It belongs to Laxatives , Laxatives pharmacological group on the basis of mechanism of action.

Molecular Weight: 362.3 · Solubility in Water: highly soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Lactitol Monohydrate.

Molecular structure of Lactitol Monohydrate

Pharmacokinetics

Elimination: renal excretion is greater than 2 % in urine and 6.5 % in feces.

Indications

Lactitol Monohydrate is primarily indicated in conditions like Constipation, Hepatic encephalopathy.

Contraindications

None recorded.

Dosage

Lactitol Monohydrate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
22.5 ml	22.5 ml	—	PO	in the morning or evening at meal time
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Lactitol Monohydrate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Abdominal distension, Anal pruritus, Cramps , dyspepsia, Epigastric pain, Flatulence, Nausea, Vomiting .

Warnings / Precautions

Absorption of lactate from colonic metabolism of lactitol can potentyially result in acid- base disturbances, and diarrhoea induced by lactitol can be associated with hypokalemia and hypernatremia. potassium deficiency may increae the risk of toxic effects of glycoisde in patients receiving concomitnt therapy. periodic monitoring of serum electrolytes, blood glucose and blood lactate is suggested.if watery stools are noticed, one should either reduce the quantity of administration or suspend administration.Blood electrolyte levels should be monitored regularly in elderly or debilitated patients on long term treatment. Patient who complain of nausea should be advised to take with meal. lactitol is not recommeded in case of ileostomy or colostomy. Fecal impaction should be treated by alternative methods prior to using lactitol.

Available Brands

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Single Ingredient

Syrup

3.35 g/5ml

Storage Conditions

Lactitol Monohydrate should be stored syrup (improper storage may deterioate the medicine). Sachet (improper storage may deterioate the medicine).

Drug Classification

1.17.6 — Laxatives

Manufacturers

Manufacturers of Lactitol Monohydrate in Pakistan:

Sami