iloperidone

Drug #2282

iloperidone is an atypical antipsychotic agent indicated for the treatment of schizophrenia in adults. it belongs to the chemical class of piperidinyl-benzisoxazole derivatives. Its chemical name is 4'-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone. Its molecular formula is C24H27FN2O4 and its molecular weight is 426.48. The structural formula is: iloperidone Structural Formula Illustration

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Primary Characteristics

It is of Synthetic origin and belongs to piperidinyl-benzisoxazole derivatives..

It is classified in Antipsycatic pharmacological group.

Molecular Weight: 426.48 · Solubility in Water: insoluble · Solubility in Alcohol: freely soulble · Non-proprietary name: iloperidone.

Pharmacokinetics

Absorption: iloperidone has an oral bioavailability is 90%.

Distribution: iloperidone has a volume of distribution is 1340 to 2800 L. plasma protein binding is approx 95%.

Elimination: it is metabolised via hepatic, plasma half-life is 18-33hrs, renal excretion is urine and feces.

Indications

iloperidone is primarily indicated in conditions like Schizophrenia.

Contraindications

None recorded.

Dosage

iloperidone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
18 mg	18 mg	—	PO	this target dosage range is achieved by daily doseage adjustments, altering patients to symptoms of orthostatic hypotension, starting at a dose of 1mg twice daily, then moving to 2 mg, 4mg, 6mg, 8mg, 10 mg, and 12mg twice dily on day2,3,4,5,6 and 7 respectively to reach 12 mg/day to 24mg/day dose range.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

4 interactions

N/A1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

iloperidone is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Dry mouth, Fatigue, Nasal congestion , Orthostatic hypotension, Somnolence , Tachycardia, Weight gain.

Warnings / Precautions

eldery patient with demntia related phychosis are not approved to treat with iloperidone Abrupt discontinuation is not advised • Cognitive and motor impairment risk • Concomitant use with drugs that prolong the QT interval should be avoided • Diabetes mellitus or risk factors for diabetes mellitus; increased risk of severe hyperglycemia • Dysphagia risk (risk of aspiration) • Exposure to extreme temperatures (hypothermia) • Elderly patients, particularly elderly women, are at increased risk of tardive dyskinesia • Hematological disease (neutropenia, agranulocytosis, etc) • Hepatic disease • Hypotensive medication use, low BP • Increased duration of therapy and/or higher cumulative doses • Seizure disorder, history, or conditions which lower seizure threshold • Substance abuse history • Risk of suicide • Tardive dyskinesia, potentially irreversible

Interference in Pathology

iloperidone may interfere in the diagnosis of Fasting blood glucose testing, change in Cholestrol level, change in triglycerides, change in lipids.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

12 mg 2 mg 4 mg 6 mg

Storage Conditions

iloperidone should be stored tablet.

Drug Classification

1.24.1 — Drugs used in psychotic disorders

Manufacturers

Manufacturers of iloperidone in Pakistan:

Genix