Tazarotene
Tazarotene is a pro-drug of the more water soluble tazarotenic acid and member of the acetylenic class of retinoids; represented by chemical formula: C21H21NO2S. Its chemical name is Ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinate. Tazarotene is a a receptor-selective and binds to RAR-beta and RAR-gama and weakly to RAR-alpha.Tazarotenic acid does not interconvert to any other retinoids that could potentially activate other retinoid receptors. In psoriasis, tazarotene normalizes keratinocyte differentiation, reverses keratinocyte hyperproliferation and has anti-inflammatory effects. In acne vulgaris, the abnormal desquamation of the follicular epithelium is normalized.
Primary Characteristics
It belongs to acetylenic class of retinoids.
It is classified in Anti Acne , Antipsoriatics , Antipsoriatics pharmacological group.
Molecular Weight: 351.46 · pKa: 1.5 · Non-proprietary name: Tazarotene.

Pharmacokinetics
Distribution: Tazarotene has a plasma protein binding is greater than 99% for tazarotenic acid.
Elimination: it is metabolised via to sulfoxides, sulfones& polar metabolites, plasma half-life is 18 hours, renal excretion is through urinary and fecal pathway..
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Indications
Tazarotene is primarily indicated in conditions like Acne vulgaris, Psoriasis vulgaris.
Contraindications
Tazarotene is contraindicated in conditions like Pregnancy, Hypersensitivity to the drug.
Dosage
Tazarotene's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0 – 0 | — | Every 24h | topical | Cleanse the face gently. After the skin is dry, apply a thin film of tazarotene 0.1% (2 mg/cm²) once a day, in the evening, to the skin where lesions appear. Apply to no more than 20% of body surface area. If a bath or shower is taken prior to application, the skin should be dry before applying the gel. If emollients are used, they should be applied at least an hour before its application. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Tazarotene are Hypervitaminosis , Redness.
Tazarotene is known to cause more or less tolerable side effects which are usually transient. These include Burning, Desquamation , Dry skin, Erythema, Irritation, Pruritus , Skin discoloration, Stinging.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.13.5.1 — Antiacne preparations
- 2.13.9 — Anti-psoriatics