DrugInfoSys

Desogestrel

Drug #221

Desogestrel is a sex hormone and used for oral contraception (to prevent pregnancy) in combinaiton with an oestrogenic hormone or to regulate menstrual cycle.

Primary Characteristics

It is of Synthetic origin and belongs to Steroid.

It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Contraceptive Oral pharmacological group. It is also classified under Sex Hormones .

Molecular Weight: 310.5 · Solubility in Water: Soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Desogestrel.

Molecular structure of Desogestrel

Pharmacokinetics

Absorption: Desogestrel has an oral bioavailability is 71.5% (±9.5%).

Distribution: Desogestrel has a volume of distribution is 1.5 l/kg. plasma protein binding is 97.5%.

Elimination: it is metabolised via Hepatic, plasma half-life is 30 hr.

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Indications

Desogestrel is primarily indicated in conditions like Acne, Contraception, Hirsutism.

Contraindications

Dosage

Desogestrel's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
100 mcg100 mcgEvery 24hPOTake regularly for 21 days followed by 7-day rest period after each month.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions
1 interaction
Minor1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Desogestrel in overdosage may give rise to further complications which include Blindness , Hypertension , Blood clotting disorder, blockage of blood vessel, Double Vission, Heart Attack.

Desogestrel produces potentially life-threatening effects which include Venous thromboembolism, Ischemic heart disease, Cerebrovascular disease, Venous thromboembolism, Cerebrovascular disease, Cerebrovascular stroke. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Desogestrel are Nausea, Vomiting, Headache, Vaginal bleeding.

Desogestrel is known to cause more or less tolerable side effects which are usually transient. These include Amenorrhea, Breast tension, Changes in body weights, Changes in libido , Depressive moods, Fluid retention, Headache, Irregular bleeding, Migraine , Nausea, Vomiting .

Warnings / Precautions

Desogestrel should be used with caution in patients with medical history, including family medical history, especially if have asthma, high blood pressure, kidney, liver or heart disease, history of jaundice (yellowing of skin or eyes) or high blood pressure during pregnancy, excessive weight gain or fluid retention during menstrual cycle, strokes, blood clots, heart attacks, seizures, migraine headaches, breast cancer, high blood level of cholesterol or lipids (fats) or depression.Higher strengths are more likely to cause melasma (darkening of skin), sunlight may intensify this darkening, so need to avoid prolonged sun exposure and sunlamps, consult the doctor regarding use of sunscreens and protective clothing.This medication must be discontinued if a women suspect to be pregnant. Avoid desogestrel during lactation. Birth-control pills slightly increase risk of strokes, blood clots, high blood pressure, heart attacks, gallbladder disease, vision problems and liver tumors.Cigarette smoking (especially 15 or more cigarettes daily) and age (women older than 35 or 40 years of age) further increase the risk of stroke, blood clots, high blood pressure and heart attacks. If patients are near-sighted or wear contact lenses, it may develop vision problems, also tolerance of the lenses may decrease, contact the eye doctor if these problems occur. Before having surgery, including dental surgery, tell the doctor about taking birth-control pills.

Interference in Pathology

Desogestrel may interfere in the diagnosis of Serum tests for adrenal corticosteroids. , Urine tests for 17-ketosteroids and 17-OH-Corticosteroids & Aldosterone. , Thyopac Method for measurement of T-3 Levels. .

Available Brands

None recorded.

Storage Conditions

Desogestrel should be stored Tab.

Drug Classification

  1. 1.18.3.1Hormonal contraceptives