Desogestrel
Desogestrel is a sex hormone and used for oral contraception (to prevent pregnancy) in combinaiton with an oestrogenic hormone or to regulate menstrual cycle.
Primary Characteristics
It is of Synthetic origin and belongs to Steroid.
It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Contraceptive Oral pharmacological group. It is also classified under Sex Hormones .
Molecular Weight: 310.5 · Solubility in Water: Soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Desogestrel.

Pharmacokinetics
Absorption: Desogestrel has an oral bioavailability is 71.5% (±9.5%).
Distribution: Desogestrel has a volume of distribution is 1.5 l/kg. plasma protein binding is 97.5%.
Elimination: it is metabolised via Hepatic, plasma half-life is 30 hr.
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Indications
Desogestrel is primarily indicated in conditions like Acne, Contraception, Hirsutism.
Contraindications
Desogestrel is contraindicated in conditions like Diabetes mellitus, Hypertension, Migraine, Thrombosis, Breast cancer, Vaginal bleeding, Systemic lupus erythematosus, Sickle cell anaemia, Circulatory system disease, Liver diseases, Otosclerosis, Atrial fibrillation, Hydatidiform mole, Porphyria, Disturbance of lipid metabolism, Valvular heart disease, Carcinoma of endometrium, Varicose veins.
Dosage
Desogestrel's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mcg | 100 mcg | Every 24h | PO | Take regularly for 21 days followed by 7-day rest period after each month. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Desogestrel in overdosage may give rise to further complications which include Blindness , Hypertension , Blood clotting disorder, blockage of blood vessel, Double Vission, Heart Attack.
Desogestrel produces potentially life-threatening effects which include Venous thromboembolism, Ischemic heart disease, Cerebrovascular disease, Venous thromboembolism, Cerebrovascular disease, Cerebrovascular stroke. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Desogestrel are Nausea, Vomiting, Headache, Vaginal bleeding.
Desogestrel is known to cause more or less tolerable side effects which are usually transient. These include Amenorrhea, Breast tension, Changes in body weights, Changes in libido , Depressive moods, Fluid retention, Headache, Irregular bleeding, Migraine , Nausea, Vomiting .
Warnings / Precautions
Interference in Pathology
Desogestrel may interfere in the diagnosis of Serum tests for adrenal corticosteroids. , Urine tests for 17-ketosteroids and 17-OH-Corticosteroids & Aldosterone. , Thyopac Method for measurement of T-3 Levels. .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.3.1 — Hormonal contraceptives