Desipramine (HCl)

Drug #219

Desipramine (HCl) is a tricyclic antidepressant. Desipramine (HCl) is the monodemethyl derivative of imipramine and Desipramine (HCl) is less sedating than its parent compound. Two to three weeks are required to obtain the full effects of the drug. It may also be used to treat nerve pain, insomnia and bed-wetting in children.

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Primary Characteristics

It is of Synthetic origin and belongs to Imipramine.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 302.8 · pK_a: 10.2 · Solubility in Water: 1 in 20 · Solubility in Alcohol: 1 in 20 · Non-proprietary name: Desipramine (HCl).

Molecular structure of Desipramine (HCl)

Pharmacokinetics

Absorption: Desipramine (HCl) has an oral bioavailability is 92.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 70%.

Distribution: Desipramine (HCl) has a volume of distribution is 22-23 l/kg. plasma protein binding is 90%.

Elimination: it is metabolised via via liver, plasma half-life is 23 hr, renal excretion is major.

Indications

Desipramine (HCl) is primarily indicated in conditions like Cocaine addiction, Depression prophylaxis, Depression treatment, Enuresis.

Contraindications

Desipramine (HCl) is contraindicated in conditions like Cardiac arrhythmia, Mania, Myocardial infarction, Heart block, Hepatic disease, Narrow-angle glaucoma, Urinary retention.

Dosage

Desipramine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
150 mg/day	150 mg/day	—	PO	May be Increased gradually to 300 mg/day.
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown13 interactions

5 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Desipramine (HCl) in overdosage may give rise to further complications which include Hepatitis , Agranulocytosis .

The signs and symptoms that are produced after acute overdosage of Desipramine (HCl) are Hypotension, Coma, Epileptic seizures, Respiratory depression, Respiratory depression, Tremor, Ventricular arrhythmias, Delayed cardiac conduction, Respiratory depression.

Desipramine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Allergic skin reactions, Anxiety, Blurred vision, Confusion, dizziness, Drowsiness, Dry mouth, Erectile impotence, Headache, Mydriasis, Nausea, Palpitation, Photosensitivity, Postural hypotension, Pruritus , Sedation , Sleep disturbancesX, Tremor, Urinary retention, Urinary RetentionX, Vasculitis, Weight gain, Xerostomia .

Warnings / Precautions

Desipramine should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses of tetracyclines. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures, sunscreens etc, against exposure to UV light or sun light.

Available Brands

None recorded.

Storage Conditions

Desipramine (HCl) should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression