deferoxamine
Also known as: Desferrioxamine
Deferoxamine is iron chelator. Deferoxamine is used in the treatment of acute iron poisoning and in conditions in which excessive iron is stored in tissues.
Primary Characteristics
deferoxamine is also known as Desferrioxamine.
It is of Semi Synthetic origin and belongs to Methanesulfonate.
It is classified in Chelating Agent pharmacological group.
Molecular Weight: 656.8 · Solubility in Water: 1 in 5 · Solubility in Alcohol: 1 in 2 · Non-proprietary name: Deferoxamine.
Pharmacokinetics
Distribution: deferoxamine has a volume of distribution is 2.9 l/kg.
Elimination: it is metabolised via in plasma, plasma half-life is 6 hr, renal excretion is 15-65%.
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Indications
deferoxamine is primarily indicated in conditions like Acute iron poisoning, Aluminium related bone disease, Aluminium -related encephalopathy, Anaemia, Blood transfusion, Chronic iron overload, Haemochromatosis, Hemochromatosis, Iron poisoning, Ocular siderosis, Transfusion-related iron overlaod.
Contraindications
deferoxamine is contraindicated in conditions like Renal impairment.
Dosage
deferoxamine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg/kg/hr | 15 mg/kg/hr | — | Cont. IV-inf | For acute Iron poisoning Max. 80 mg/kg in 24 hrs |
| 0.75 g | 0.75 g | — | IM | For Chronic Iron over Load.This dose is given as initial dose and maintainence dose is determined by response. |
| 5 mg/kg/hr | 5 mg/kg/hr | — | IV-inf | For aluminium over load. |
| 500 mg | 500 mg | — | SC inf or IV inf | For Chronic Iron over Load.Usual effective dose is 20-60 mg/kg.Subcutaneous infusions are given 3-7 times a week (usually over 8-12 hours ) depending on the degree of iron load |
| 10 % | 10 % | — | topical | As eye drops for the treatment of Ocular siderosis and corneal rust stains |
| Paediatric Dosage (20kg) | ||||
| 28.571 mg/kg | 28.571 mg/kg | Every 24h | Intra Muscular | Initial |
| 71.428 mg/kg | 71.428 mg/kg | — | Oral | Maintenance, As Required |
| Neonatal Dosage (3kg) | ||||
| 28.571 mg/kg | 28.571 mg/kg | Every 24h | Intra Muscular | Initial |
| 71.428 mg/kg | 71.428 mg/kg | — | Oral | Maintenance, As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
deferoxamine in overdosage may give rise to further complications which include Hypotension , Hypotension .
deferoxamine produces potentially life-threatening effects which include Cardiac arrhythmia, Anaphylaxis , Tachypnea, Hypoxemia , Hypoxemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of deferoxamine are Bradycardia, Hypotension, Loss of vision, Aphasia.
deferoxamine is known to cause more or less tolerable side effects which are usually transient. These include Allergy , Asymptomatic electro-retinographic abnormalities, Discomfort , Electro-oculographic abnormalities, Field defects, Hearing loss, Legcramps, Night blindness, Optic neuritis, Pupillary abnormalities, Redness, Reduced visual acuity, Retinal pigmentary changes, Swelling .
Warnings / Precautions
Interference in Pathology
deferoxamine may interfere in the diagnosis of Colorimetric measurement of iron concentrations in any body fluid. , Spot Testing of Urine for drugs. .
Available Brands
Storage Conditions
Drug Classification
- 1.4.2.4 — Iron poisoning and iron & aluminium overload