Gemifloxacin

Drug #2176

Gemifloxacin belongs to Flouroquinolone, which are used for management of various bacterial infections. It kills a variety of bacteria, and prevent their reproduction and is often used for the treatment of infections all over the body. However, they are not considerably good for the management of viral infections like flu. Gemifloxacin inhibits the synthesis of DNA by inhibiting DNA gyrase and topoisomerase IV is the enzyme which is needed for bacterial growth.

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Primary Characteristics

Gemifloxacin is also known as Gemifloxacin mesilate, Gemifloxacin mesylate.

It is of Synthetic origin and belongs to Flouroquinolones.

It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Aminoquinolines , Aminoquinolines pharmacological group.

Molecular Weight: 485.5 · Solubility in Water: soluble · Non-proprietary name: Gemifloxacin.

Pharmacokinetics

Absorption: Gemifloxacin has an oral bioavailability is 35.5% (±35.5%).

Distribution: Gemifloxacin has a volume of distribution is 4.2 L/kg. plasma protein binding is 55-73%.

Elimination: it is metabolised via hepatic, plasma half-life is 7 hr, renal excretion is 36.

Indications

Gemifloxacin is primarily indicated in conditions like Bacterial infections, Chronic bronchitis, Cold, Lower respiratory tract infections, Pneumonia, Upper respiratory tract infections.

Gemifloxacin is also indicated for secondary conditions like Diarrhoea.

Contraindications

Gemifloxacin is contraindicated in conditions like Hypersensitivity.

Dosage

Gemifloxacin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
320 mg daily	320 mg daily	Every 24h	PO	Doses should be reduced if patient has kidney problem. (For 5 days in patients with bronchitis or 7 days in patients with pnerrmonia)
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Gemifloxacin in overdosage may give rise to further complications which include Jaundice , Jaundice , Seizures , Bleeding , Diarrhea, Tremors .

Gemifloxacin produces potentially life-threatening effects which include QT prolongation. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Gemifloxacin are Convulsions , Kidney failure, Confusion , Stomach upset, Headache, Delusions .

Gemifloxacin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Dizziness, Irritability, Nausea and vomiting, Rashes , Restlessness.

Warnings / Precautions

Should be use with caution in patients with epilepsy or history of seizures, pregnant or breastfeeding patients.Gemifloxacin should be stopped at the first sign of a skin rash or any other allergic reaction nad seek for medical doctor. Though rare, serious and seldom fatal allergic reactions have been reported, even after the first dose.

Interference in Pathology

Gemifloxacin may interfere in the diagnosis of Aspartate Aminotransferase Assay , Bilirubin (increased level), Increased level of alanine aminotransferase, GGT Increased.

Available Brands

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Single Ingredient

Caps

320 mg

Tabs

320 mg

Multi-Ingredient Combinations

Tabs

320 mg

Storage Conditions

Gemifloxacin should be stored tabs.

Drug Classification

1.6.2.2.2 — Quinolones