Piroxicam-beta-cyclodextrin
Also known as:
Piroxicam-beta-cyclodextrin is a complex of the nonsteroidal antiinflammatory drug (NSAID) piroxicam and an inert cyclic macromolecule, beta-cyclodextrin. In clinical trials in patients with pain or rheumatic diseases arising from other conditions, it was as effective an analgesic as standard piroxicam, and showed a faster onset of action on the first day of treatment. In healthy volunteers short term pharmacodynamic studies showed, piroxicam-beta-cyclodextrin was equivalent to or tended to show less gastrointestinal mucosal toxicity than standard piroxicam, as evaluated by endoscopy and faecal blood loss
Primary Characteristics
Piroxicam-beta-cyclodextrin is also known as .
It is of Synthetic origin and belongs to Oxicam.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 331.4 · pKa: 6.3 · Solubility in Water: slightly soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Piroxicam-beta-cyclodextrin.
Pharmacokinetics
Absorption: Piroxicam-beta-cyclodextrin has an oral bioavailability is 50% (±50%).
Distribution: Piroxicam-beta-cyclodextrin has a plasma protein binding is 99%.
Elimination: it is metabolised via hepatic, plasma half-life is 30-60 hours.
Advertisement
Indications
Piroxicam-beta-cyclodextrin is primarily indicated in conditions like Acute gout, Acute musculoskeletal disorders, Acute pain, Ankylosing spondylitis, Backache, Dysmenorrhoea, Juvenile chronic arthritis, Migraine, Osteoarthritis, Post operative pain, Rheumatic diseases.
Piroxicam-beta-cyclodextrin is also indicated for secondary conditions like Juvenile rheumatoid arthritis.
Contraindications
Piroxicam-beta-cyclodextrin is contraindicated in conditions like Asthma, Peptic ulcer, Thrombosis, Rhinitis, Urticaria, Impaired hepatic function, Angioedema, Hypersensitivity.
Dosage
Piroxicam-beta-cyclodextrin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg | 15 mg | Every 1h | IM | For orthopedic surgery administer 40 mg OD for 2 days followed by 20 mg OD |
| 15 mg | 15 mg | Every 1h | PO | For orthopedic surgery administer 40 mg OD for 2 days followed by 20 mg OD |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Piroxicam-beta-cyclodextrin in overdosage may give rise to further complications which include Skin reactions , Erythema , Interstitial nephritis .
Piroxicam-beta-cyclodextrin produces potentially life-threatening effects which include GI bleeding, Aplastic Anemia , Renal damage, Peptic ulceration, Purpura , Pemphigus vulagris. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Piroxicam-beta-cyclodextrin are Hematuria, Diarrhea, Convulsions , Acute renal failure, GI bleeding, Vomiting, Hyperventilation, Coma, Rashes , Hypoprothrombinemia, Nausea, Proteinuria, hyper reflexia, Headache, Hyperreflexia , Dizziness, Tinnitus .
Piroxicam-beta-cyclodextrin is known to cause more or less tolerable side effects which are usually transient. These include Azotemia, bronchoconstriction, Diarrhea, Edema, Erythema multiforme, GI disturbance, Nausea and vomiting, Skin irritation.
Warnings / Precautions
Interference in Pathology
Piroxicam-beta-cyclodextrin may interfere in the diagnosis of Auditory function test.
Available Brands
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)
Manufacturers
Manufacturers of Piroxicam-beta-cyclodextrin in Pakistan: