Pregabalin
Also known as: gabapentin
Pregabalin, is the first drug approved by FDA for the treatment of fibromyalgia. Lyrica is also used for the relieve of nerve pain or seizures. Pregabalin is chemically similar to the drug Neurontin (gabapentin).
Primary Characteristics
Pregabalin is also known as gabapentin.
It is of Synthetic origin.
Molecular Weight: 159.23 · pKa: pKa1 4.2 and pKa2 10.6 · Solubility in Water: soluble · Non-proprietary name: Pregabalin.
Pharmacokinetics
None recorded.
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Indications
Pregabalin is primarily indicated in conditions like Adjunctive treatment of partial seizures, Epilepsy, Fibromyalgia, Neuropathic pain.
Contraindications
Pregabalin is contraindicated in conditions like Hypersensitivity.
Dosage
Pregabalin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg/day | 75 mg/day | Every 1h | Oral | This dose is for neuropathic pain associated with diabetic peripheral neuropathy and for epilepsy .Reduce the dose to 75 mg when creatinine clearance is 30-60 ml/ min and up to 25-50 mg when creatinine clearance is 15-30 ml/min or below that |
| 75 mg/day | 75 mg/day | Every 1h | Oral | This dose is for management of Fibromyalgia. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 450 mg/day (225mg twice a day) |
| 75 mg/day | 75 mg/day | — | Oral | This dose is for adjunctive therapy for adult patients with partial onset seizures. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Pregabalin in overdosage may give rise to further complications which include Chest pain .
Pregabalin produces potentially life-threatening effects which include Chest pain, Suicidal action, jerking. Careful monitoring is needed with proper medical management.
Pregabalin is known to cause more or less tolerable side effects which are usually transient. These include Abnormal thinking, Blurred vision, Constipation , Diplopia, Dizziness, Dry mouth, Edema, Flatulence, Increased appetite, Somnolence , Vomiting , Weight gain.
Warnings / Precautions
Interference in Pathology
Pregabalin may interfere in the diagnosis of Elevaions in creatinine phosphokinase levels.
Available Brands
Storage Conditions
Drug Classification
- 1.5 — Anticonvulsants and Antiepileptics