Debrisoquine (Sulphate)
Also known as: Isocaramidine Sulphate
Chemically Debrisoquine (Sulphate) is 3, 4-dihydro-2(1H)-isoquinolinecarboxamidine. Debrisoquine (Sulphate) is adrenergic neurone blocking agent. Debrisoquine (Sulphate) is used in hypertension to lower the blood pressure.
Primary Characteristics
Debrisoquine (Sulphate) is also known as Isocaramidine Sulphate.
It is of Synthetic origin and belongs to Isoquinoline.
It is classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 448.5 · pKa: 11.9 · Solubility in Water: > 1 in 40 · Solubility in Alcohol: > 1 in 10000 · Non-proprietary name: Debrisoquine (Sulphate).
Pharmacokinetics
Absorption: Debrisoquine (Sulphate) has an oral bioavailability is 77.5% (±7.5%).
Distribution: Debrisoquine (Sulphate) has a plasma protein binding is 25%.
Elimination: it is metabolised via Hepatic, plasma half-life is 10-26 hr, renal excretion is 80-90%.
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Indications
Debrisoquine (Sulphate) is primarily indicated in conditions like Hypertension.
Debrisoquine (Sulphate) is also indicated for secondary conditions like Amoebic dysentry, Granulomatous disease, Skin lesions.
Contraindications
Debrisoquine (Sulphate) is contraindicated in conditions like Phaeochromocytoma, Renal failure.
Dosage
Debrisoquine (Sulphate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg/kg | 15 mg/kg | Every 24h | PO | Initial |
| 70 mg/kg | 70 mg/kg | Every 24h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Debrisoquine (Sulphate) produces potentially life-threatening effects which include Blood pressure reduction. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Debrisoquine (Sulphate) are Orthostatic hypotension.
Debrisoquine (Sulphate) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Failure of ejaculation, Syncope .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.12.3.8 — Ganglion blocking drugs