Dehydroemetine (HCl)
Dehydroemetine (HCl) is antiprotozoal drug. Dehydroemetine (HCl) is use in the treatment of amebic dysentery (infection of intestinal tract).
Primary Characteristics
It is of Synthetic origin and belongs to Emetine.
It is classified in Amebicides pharmacological group.
Molecular Weight: 551.6 · Solubility in Water: 1 in 30 · Non-proprietary name: Dehydroemetine (HCl).
Pharmacokinetics
None recorded.
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Indications
Dehydroemetine (HCl) is primarily indicated in conditions like Amoebic dysentry, Amoebic granulomata, Hepatic amoebiasis, Skin lesions.
Contraindications
Dehydroemetine (HCl) is contraindicated in conditions like Polyneuritis, Heart disease.
Dosage
Dehydroemetine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 60 mg | 60 mg | Every 24h | IM | For 4 to 6 days. It is a max daily dose. 0.5mg/kg is given for elderly or severly ill pateints. |
| Paediatric Dosage (20kg) | ||||
| 1 mg/kg | 1 mg/kg | Every 12h | Intra Muscular | For not more than 10 Days |
| Neonatal Dosage (3kg) | ||||
| 0.6 mg/kg | 0.6 mg/kg | Every 12h | Intra Muscular | For not more than 10 Days |
Drug Interactions
None recorded.
Side Effects
Dehydroemetine (HCl) produces potentially life-threatening effects which include Myocarditis . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Dehydroemetine (HCl) are Myocardial toxicity.
Dehydroemetine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include ECG changes, Giddiness, Headache, Local pain, Nausea, Pain at injection site, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.4.1 — Antiamebic & antigiardiasis drugs