Paregoric

Drug #2030

Paregoric, or camphorated tincture of opium, is a medication known for its antidiarrheal, antitussive, and analgesic properties. It was a household remedy in the 18th and 19th centuries, when it was widely used to calm fretful children.

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Primary Characteristics

Non-proprietary name: Paregoric.

Pharmacokinetics

Elimination: it is metabolised via Hepatic, plasma half-life is 2-3 hrs.

Indications

Paregoric is primarily indicated in conditions like Diarrhoea.

Contraindications

Paregoric is contraindicated in conditions like Convulsions, Tetanus, Hypersensitivity to any component of product.

Dosage

Paregoric's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7.5 ml	7.5 ml	—	PO	1-4 times daily.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Major4 interactions

Minor1 interaction

Moderate10 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Paregoric in overdosage may give rise to further complications which include Pruritis , Constipation .

The signs and symptoms that are produced after acute overdosage of Paregoric are Bradycardia, Hypotension, Death , Apnea, Coma, Respiratory depression, Respiratory depression, Cardiac arrest, Dysphoria , Somnolence, Euphoria .

Paregoric is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Light headedness, Nausea and vomiting, Sedation .

Warnings / Precautions

Paregoric should be used with extreme caution in patients with disorders characterized by hypoxia, since even usual therapeutic doses of narcotics may decrease respiratory drive to the point of apnea while simultaneously increasing airway resistance. Because of a possible vagolytic action that may produce a significant increase in the ventricular response rate, Paregoric should be used with caution in patients with atrial flutter and other supraventricular tachycardias. Paregoric appears in the milk of nursing mothers. Caution should be exercised when paregoric is administered to a nursing woman. Animal reproduction studies have not been conducted with morphine. It is not known whether morphine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Paregoric should be given to a pregnant woman only if clearly needed. This preparation should not be used in diarrhea caused by poisoning until the toxic material is eliminated from the gastrointestinal tract.

Available Brands

None recorded.

Storage Conditions

Paregoric should be stored .

Drug Classification

1.17.7.2 — Antidiarrheals