Nimorazole

Drug #2009

Nimorazole is a 5-nitroimidazole derivative. It has antimicrobial actions and uses similar to those of metronidazole.

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Primary Characteristics

It belongs to Nitroimidazole.

Molecular Weight: 226.2 · Non-proprietary name: Nimorazole.

Pharmacokinetics

Elimination: renal excretion is Urine.

Indications

Nimorazole is primarily indicated in conditions like Amoebiasis, Giardiasis, Trichomoniasis.

Nimorazole is also indicated for secondary conditions like Gingivitis.

Contraindications

Nimorazole is contraindicated in conditions like Liver diseases, Hypersensitivity, Pregnancy, Kidney disease, Breast feeding.

Dosage

Nimorazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 mg	250 mg	—	PO	For the treatment of trichomoniasis 3 times daily for 5-7 days.
250 mg	250 mg	—	PO	For the treatment of giardiasis 2 times daily for 5-7 days.
500 mg	500 mg	—	PO	For the treatment of gingivitis 2 times daily for 2 days.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

The signs and symptoms that are produced after acute overdosage of Nimorazole are Convulsions , Seizures, Leucopenia , Peripheral neuropathy.

Nimorazole is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Ataxia, Diarrhea, Dizziness, Drowsiness, Heart burn, Insomnia, Itching, Nausea and vomiting, Pain , Skin rashes.

Warnings / Precautions

During treatment is not recommended to drink alcoholic beverages. Peripheral neuropathy, transient epileptiform seizures, and leucopenia have sometimes been associated with prolonged or intensive treatment with Nimorazole. Clinical and laboratory monitoring is advised in patients receiving Nimorazole for more than 10 days. Doses should be reduced in patients with severe hepatic impairment. It is suggested that the use of Nimorazole should be avoided during pregnancy, and this caution applies especially to use during the first trimester and to the use of high-dose regimens.

Available Brands

None recorded.

Drug Classification

1.6.4.1 — Antiamebic & antigiardiasis drugs