Nitrendipine
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
Primary Characteristics
Molecular Weight: 360.4 · Solubility in Water: Insoluble · Solubility in Alcohol: Sparingly soluble · Non-proprietary name: Nitrendipine.
Pharmacokinetics
Absorption: Nitrendipine has an oral bioavailability is 15% (±5%).
Distribution: Nitrendipine has a plasma protein binding is 98%.
Elimination: it is metabolised via Hepatic, plasma half-life is 8.6 hrs, renal excretion is Urine.
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Indications
Nitrendipine is primarily indicated in conditions like Mild to moderate hypertension.
Contraindications
Nitrendipine is contraindicated in conditions like Hypotension, Aortic stenosis, Hypersensitivity to any component of product.
Dosage
Nitrendipine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 20 mg/day | 20 mg/day | — | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Nitrendipine are Bradycardia, Confusion , Hyperglycemia, myocardial depression.
Nitrendipine is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Edema, Fatigue, Flushing, Gingival hyperplasia, Headache, Nausea, Palpitation, vasodialation.
Warnings / Precautions
Available Brands
None recorded.
Drug Classification
- 1.12.3.2 — Calcium antagonists
- 2.12.3.7 — Direct vasodilators