Methicillin Sodium

Drug #1998

Methicillin Sodium is a narrow spectrum beta-lactam antibiotic. It was previously used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins, but is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.

← Previous drug Next drug →

Primary Characteristics

It is of Semi Synthetic origin.

It is classified in Penicillinase-sensitive Penicillin pharmacological group.

Molecular Weight: 420.4 · Non-proprietary name: Methicillin Sodium.

Molecular structure of Methicillin Sodium

Pharmacokinetics

Distribution: Methicillin Sodium has a plasma protein binding is 40%.

Elimination: it is metabolised via Hepatic(20-40%), plasma half-life is 25-60 mins, renal excretion is 80%.

Indications

Methicillin Sodium is primarily indicated in conditions like Staphlococcal infections.

Contraindications

Methicillin Sodium is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

None recorded.

Drug Interactions

None recorded.

Side Effects

Methicillin Sodium in overdosage may give rise to further complications which include Hemolytic anemia , Hemolytic anemia , Neutropenia , Acute interstitial nephritis , Hemolytic anemia.

Methicillin Sodium produces potentially life-threatening effects which include Encephalopathy , Anaphylaxis . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Methicillin Sodium are Jaundice , Jaundice, Hepatitis, Nephropathy, Nephritis.

Methicillin Sodium is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Hypersensitivity reactions, Nausea, Pseudomembranous colitis , Skin rashes.

Warnings / Precautions

Patients known to be hypersensitive to penicillins should be given an antibacterial of another class. However, sensitised patients may also react to the cephalosporins and other beta lactams. Penicillins should be given with caution to patients with a history of allergy, especially to drugs. Skin contact with penicillins should be avoided since sensitisation may occur. Penicillin therapy changes the normal bacterial flora and can lead to supra-infection with penicillin-resistant organisms including Clostridium difficile or Candida, particularly with prolonged use. Care is necessary if very high doses of penicillins are given, especially if renal function is poor, because of the risk of neurotoxicity.

Interference in Pathology

Methicillin Sodium may interfere in the diagnosis of Thyroid Function Test.

Available Brands

None recorded.

Drug Classification

1.6.2.1.1 — Penicillins